Results 31 to 40 of about 1,737,272 (214)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

π−-induced production of K0Λ pairs on nuclei at 1.15 GeV/c momentum

EPJ Web of Conferences, 2012
In this article we present study of π− induced production of K0Λ pairs on nuclei at 1.15 GeV/c momentum. Experiment was performed at FOPI spectrometer in GSI in Germany.
Matulewicz T., Kasparek A.
doaj   +1 more source

Optical and Current Measurements of Lightning Attachment to the 356-m-High Shenzhen Meteorological Gradient Tower in Southern Coastal Area of China

IEEE Access, 2019
This paper presents in detail the instrumentation for coordinated optical and current measurements of lightning discharges to a 356-m-high meteorological tower and the observation results. The tower, which is located at Shenzhen, a lower latitude coastal
Zongxu Qiu, Yuexin Yang, Zilong Qin, Mingli Chen, Fanchao Lyu, Hongbo Guo, Ya-Ping Du, Yan Gao, Ge Zhang, Shaoyang Wang   +9 more
doaj   +1 more source

Outer membrane permeabilization is an essential step in the killing of gram-negative bacteria by the lectin RegIIIβ. [PDF]

PLoS ONE, 2013
The C-type lectin RegIIIβ can kill certain Gram-positive and Gram-negative bacteria. The susceptibility of S. Typhimurium depends on the bacterial growth phase, i.e., bacteria from the logarithmic growth phase do bind RegIIIβ and are subsequently killed.
Tsuyoshi Miki, Wolf-Dietrich Hardt
doaj   +1 more source

Fault Diagnosis Method for Wind Turbine Gearboxes Based on IWOA-RF

Energies, 2021
A fault diagnosis method for wind turbine gearboxes based on undersampling, XGBoost feature selection, and improved whale optimization-random forest (IWOA-RF) was proposed for the problem of high false negative and false positive rates in wind turbine ...
Mingzhu Tang, Zixin Liang, Huawei Wu, Zimin Wang   +3 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Scour reduction downstream of a sluice gate using stepped basins under submerged hydraulic jump condition

Water Science
This study experimentally examined the performance of pooled stilling basins with positive and negative steps, with and without baffle blocks, for mitigating local scour and enhancing energy dissipation downstream of sluice gates. The study combined 1, 2,
Wail A. Fahmy, M. M. Ibrahim, Salma A. Nofal, Eslam El Tohamy   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source