Results 151 to 160 of about 6,709,602 (308)

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia

BACKGROUND: Schizophrenia is characterized by widespread structural brain abnormalities, but associations between structural abnormalities and negative symptom severity are not well understood. Negative symptoms have been conceptualized in a hierarchical
Quid\ue9, Yann, Bernardoni, Fabio, Kamalakannan, So M V, Vecchio, Daniela, Pantelis, Christos, Carr, Vaughan J, Jablensky, Assen, Kaiser, Stefan, Gur, Raquel E, Bustillo, Juan, Ehrlich, Stefan, Ford, Judith M., Calhoun, Vince D., Male, Alie G., Michie, Patricia, Scott, Rodney J., Ahmed, Anthony O., J\uf6nsson, Erik G., Satterhwaite, Theodore D, Potkin, Steven G, Preda, Adrian, Jönsson, Erik G, Lee, Jaylen, L\uf3pez-Jaramillo, Carlos, Aleman, André; id_orcid, Scott, Rodney J, Henskens, Frans A., Aleman, Andr\ue9, Carr, Vaughan J., van Erp, Theo G.M., Mowry, Bryan, Turner, Jessica A., Catts, Stanley, Mathalon, Daniel H., Gur, Ruben C, Potkin, Steven G., Borgwardt, Stefan, Male, Alie G, Banaj, Nerisa, Loughland, Carmel, Diaz-Zuluaga, Ana M, Piras, Fabrizio, Green, Melissa J., Marsman, Jan-Bernard, Quidé, Yann, Shall, Ulrich, Mueller, Bryon, Cairns, Murray J, Belger, Ayse, Cairns, Murray J., Krug, Axel, Stein, Frederike, Krischner, Matthias, Henskens, Frans A, Strauss, Gregory P., Alpert, Kate, Thompson, Paul A., Pineda-Zapata, Julian, Grotegerd, Dominik, Gur, Ruben C., Kamalakannan, SO M.V., Satterhwaite, Theodore D., Agartz, Ingrid, Salvador, Raymond, Yilan li, Musa, Pomarol-Clotet, Edith, Ford, Judith M, López-Jaramillo, Carlos, Lella, Annalisa, Lim, Kelvin, Green, Melissa J, Diaz-Zuluaga, Ana M., Dannlowski, Udo, Gur, Raquel E., Mathalon, Daniel H, Cobia, Derin, Piras, Federica, Wang, Lei, Kircher, Tilo, Lee, J, Kamalakannan, SMV, Yilan, Li M, Cairns, MJ, Male, AG, Quidé, Y, Lella, A, Catts, S, Green, MJ, Carr, VJ, Aleman, André, Kamalakannan, So M. V., van Erp, Theo G. M., Jönsson, Erik G.   +92 more
core   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Social Skills Training and Negative Symptoms

, 1992
Schizophrenic patients with severe negative symptoms may have an impaired capacity to benefit from social skills training (SST), and their negative symptoms may show little change as a result of SST.
RP Rudd (15899498), NE McMurray (15899504), N Matousek (13410363), J Edwards (7750226), HJ Jackson (14448261)   +4 more
core  

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Negative symptoms at discharge and outcome in schizophrenia

, 2012
[[abstract]]"BACKGROUND: The clinical significance in schizophrenia of positive and negative symptoms at discharge was assessed. METHOD: Of schizophrenic patients fulfilling DSM-III criteria, 113 were recruited for this study.
Yeh), 葉玲玲(Ling-Ling
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source