Results 201 to 210 of about 1,691,473 (292)

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Repurposed antihypertensive drugs for negative symptoms in schizophrenia: A systematic review and meta-analysis. [PDF]

Psychiatry Clin Neurosci
Carnaval T, Bui M, Villoria J, Rodríguez D, Menchón JM, Ciruela F, Videla S.   +6 more
europepmc   +1 more source

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

Associations between negative symptoms and resting-state functional connectivity within social brain networks among individuals with early psychosis. [PDF]

Schizophrenia (Heidelb)
Knippenberg AR, Sweet LH, Luther L, Kim S, Strauss GP.   +4 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Early career psychiatrists' ability to evaluate and manage negative symptoms of schizophrenia - Results from a European survey. [PDF]

Eur Psychiatry
Krupa AJ, Siwek M, Gondek T, Sampogna G, de Filippis R, Lengvenytė A, Özel B, Tăpoi C, Banjac Baljak V, Jerotic S, Karaliuniene R, Kjær JN, Longo G, Marinova-Djambazova P, Medved S, Milutinović M, Oliveira I, Őri D, Pinto da Costa M, Quattrone D, Rausch J, Schoretsanitis G, Sönmez Güngör E, Seker A, Sołtys Z, Szczegielniak A, Vrublevska J, Wallies M, Dudek D, Fagiolini A, Mucci A, Galderisi S.   +31 more
europepmc   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Roluperidone monotherapy, a treatment for negative symptoms in schizophrenia. [PDF]

Int J Neuropsychopharmacol
Davidson M, Noel N, Schmitt F, Luthringer R.   +3 more
europepmc   +1 more source

A Study on the Effectiveness of Metacognitive Training in Treating Negative Symptoms of Different Subtypes of Schizophrenia. [PDF]

Psychol Res Behav Manag
Shen L, Yan J, Xiao W, Sun L, Du M, He Y.   +5 more
europepmc   +1 more source

Economic Burden Associated with Negative Symptoms Identified Through Natural Language Processing Among Patients with Schizophrenia in the United States. [PDF]

Schizophr Bull
Vaccaro J, Nili M, Xiang P, Nelson JK, Pack C, Thompson R, Vasey J, Parks J.   +7 more
europepmc   +1 more source