Results 41 to 50 of about 77,031 (254)

Negative thermal expansion of two-dimensional materials: A review

Nano Research
Negative thermal expansion (NTE) in two-dimensional (2D) materials defies the traditional views of thermal expansion and holds promise for the development of advanced nanoelectronics and temperature-controlled devices. Recent advances in 2D NTE materials,
Chunxiang Zhao, Jiaqi Wang, Qiang Sun, Qilong Gao   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Controllable negative thermal expansion in NaZn13-type La(Fe, Co, Al)13 compounds

AIP Advances, 2020
Control of negative thermal expansion (NTE) is of great importance for various applications of NTE materials. Here, we report an effective way to control both the coefficient of thermal expansion (CTE) and NTE temperature-window in NaZn13-type La(Fe, Co,
Wentao Sun, Hua Zhang, Wen Li, Rongjin Huang, Yuqiang Zhao, Wei Wang, Laifeng Li   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Ionic conduction and negative thermal expansion of (H3O)Zr2(PO4)3

Studies in Science and Technology
(NH4)Zr2(PO4)3 powder synthesized by hydrothermal reaction was heat-treated at 600 °C to obtain HZr2(PO4)3 powder, which was then autoclaved in deionized water at 150 °C to prepare (H3O)Zr2(PO4)3 powder.
Susumu Nakayama, Yuri Fukuta, Koichi Nishijima, Issei Nitani, Masaki Shiomi   +4 more
doaj   +1 more source

Origin of the Giant Negative Thermal Expansion in Mn3(Cu0.5Ge0.5)N

Advances in Condensed Matter Physics, 2012
The giant negative thermal expansion in the Ge-doped antiperovskite Mn3CuN compound is theoretically studied by using the first principles calculations. We propose that such a negative thermal expansion property is essentially attributed to the magnetic ...
B. Y. Qu, H. Y. He, B. C. Pan
doaj   +1 more source

Negative thermal expansion in functional materials: controllable thermal expansion by chemical modifications

Chemical Society Reviews, 2015
Negative thermal expansion is an intriguing property of functional materials, which will give new phenomena and mechanisms for future studies.
Jun, Chen, Lei, Hu, Jinxia, Deng, Xianran, Xing   +3 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source