Results 41 to 50 of about 72,046 (253)

Negative thermal expansion of two-dimensional materials: A review

Nano Research
Negative thermal expansion (NTE) in two-dimensional (2D) materials defies the traditional views of thermal expansion and holds promise for the development of advanced nanoelectronics and temperature-controlled devices. Recent advances in 2D NTE materials,
Chunxiang Zhao, Jiaqi Wang, Qiang Sun, Qilong Gao   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Controllable negative thermal expansion in NaZn13-type La(Fe, Co, Al)13 compounds

AIP Advances, 2020
Control of negative thermal expansion (NTE) is of great importance for various applications of NTE materials. Here, we report an effective way to control both the coefficient of thermal expansion (CTE) and NTE temperature-window in NaZn13-type La(Fe, Co,
Wentao Sun, Hua Zhang, Wen Li, Rongjin Huang, Yuqiang Zhao, Wei Wang, Laifeng Li   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Negative thermal expansion in functional materials: controllable thermal expansion by chemical modifications

Chemical Society Reviews, 2015
Negative thermal expansion is an intriguing property of functional materials, which will give new phenomena and mechanisms for future studies.
Jun, Chen, Lei, Hu, Jinxia, Deng, Xianran, Xing   +3 more
openaire   +3 more sources

Ionic conduction and negative thermal expansion of (H3O)Zr2(PO4)3

Studies in Science and Technology
(NH4)Zr2(PO4)3 powder synthesized by hydrothermal reaction was heat-treated at 600 °C to obtain HZr2(PO4)3 powder, which was then autoclaved in deionized water at 150 °C to prepare (H3O)Zr2(PO4)3 powder.
Susumu Nakayama, Yuri Fukuta, Koichi Nishijima, Issei Nitani, Masaki Shiomi   +4 more
doaj   +1 more source

Origin of the Giant Negative Thermal Expansion in Mn3(Cu0.5Ge0.5)N

Advances in Condensed Matter Physics, 2012
The giant negative thermal expansion in the Ge-doped antiperovskite Mn3CuN compound is theoretically studied by using the first principles calculations. We propose that such a negative thermal expansion property is essentially attributed to the magnetic ...
B. Y. Qu, H. Y. He, B. C. Pan
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source