Results 111 to 120 of about 1,299,940 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
We provide laboratory evidence that people neglect skewness resulting from compound shocks.Skewnes, belief biases, binomial ...
Georg Weizsäcker +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Maltreated children in the Looked After System: a comparison of outcomes for those who go home and those who do not [PDF]
, 2010 This project focuses on the consequences of decisions to reunify children who had entered the looked-after system for abuse or neglect. It compares the progress and outcomes of a sample of maltreated children who either went home or remained in the ...
Biehal, N +3 more
core
Gaia 1 cannot be a Thick Disk Galactic cluster
, 2018 In this note I show how the recently suggested membership of the open cluster Gaia 1 to the Galactic thick disk is based on incorrect assumptions about the structure of the disk itself, and neglect well-known observational evidences on the disk warp and ...
Carraro, Giovanni
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Abuse and Neglect of Animals and People, An Update [PDF]
, 2017 Veterinarians have noticed for quite some time that individuals who mistreat their animals may not stop there, carrying over their behavior to spouses, parents and others.
Ansello, Edward F.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
El recuerdo de la Primera Guerra Mundial en los antiguos territorios del imperio austrohúngaro
Comillas Journal of International Relations, 2015 En el imperio austrohúngaro inevitablemente emergió una experiencia colectiva de la Gran Guerra. Sin embargo, la disolución repentina del imperio de los Habsburgo y las hostilidades inmediatas entre sus estados sucesores implicaron que nunca se llegó a ...
Christopher Brennan
doaj
Religiously-Motivated Medical Neglect: A Response to Professors Levin, Jacobs, and Arora [PDF]
, 2016 This Response to Professors Levin, Jacobs, and Arora’s article To Accommodate or Not to Accommodate: (When) Should the State Regulate Religion to Protect the Rights of Children and Third Parties?
Coleman, Doriane Lambelet
core +2 more sources