Results 111 to 120 of about 1,307,822 (311)
Book review: Social policy as a magpie : applying ruthlesspragmatism to real-world problems [PDF]
, 2012 Introducing social policy as a broadly conceived study of human wellbeing, Hartley Dean’s revised and updated Social Policy examines the ways in which governments and peoples throughout the world attend to, promote, neglect or even undermine the things ...
Miller, Jennifer
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Child Abuse and Neglect in the UK Today [PDF]
, 2011 This report presents new research findings from the NSPCC on child maltreatment in the United Kingdom, looking specifically at the prevalence and impact of severe maltreatment.
Bassett, Claire +6 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Aysha King - medical treatment and the notion of 'neglect' [PDF]
, 2014 This article discusses the legal questions relating to parental rights to remove their child from hospital, and the international ...
Ressel, James
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
El recuerdo de la Primera Guerra Mundial en los antiguos territorios del imperio austrohúngaro
Comillas Journal of International Relations, 2015 En el imperio austrohúngaro inevitablemente emergió una experiencia colectiva de la Gran Guerra. Sin embargo, la disolución repentina del imperio de los Habsburgo y las hostilidades inmediatas entre sus estados sucesores implicaron que nunca se llegó a ...
Christopher Brennan
doaj
Psychiatry and Clinical Psychopharmacology, 2019 AIM: Higher rates of childhood trauma have been reported in both children and adults with adult attention deficit hyperactivity disorder (ADHD) than in healthy individuals. The association between childhood trauma and deficiency in cognitive functions in
Zeynep Baran Tatar, Alparslan Cansız
doaj +1 more source