Results 201 to 210 of about 1,299,940 (312)

Patterns and risk factors of illicit substance abuse by Sri Lankan teenagers: a case-control study. [PDF]

BMJ Paediatr Open
Dayasiri K, Samarasinghe M, Gunarathna G, Sandakelum U, Gawarammana I.   +4 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Exploring the inter-factor network of psychological abuse, life-event stress, and suicidal behavior: evidence from Chinese college students. [PDF]

Front Psychol
Cao J, Huo Z, Liu X, Meng N, Tan T.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

The Mediating Role of Rumination in the Relationship Between Childhood Trauma and the Severity of Major Depressive Disorder. [PDF]

Psychiatry Investig
Yalım E, Mavi CÜ, Özmenler KN.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The Relationship Between Self-Neglect and Self-Efficacy for Appropriate Medication Use Among Older Adults: A Cross-Sectional Study. [PDF]

Sage Open Aging
Hasanshahi Raviz A, Farokhzadian J, Khodabandeh Shahraki S, Motamed-Jahromi M.   +3 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

From childhood struggles to adult strains: A systematic review of the impact of adverse childhood experiences on psycho-emotional functioning, pain outcomes, and quality of life in populations experiencing chronic pain. [PDF]

Br J Pain
Gkiouzeli A, Brennstuhl MJ, Couraillon A, Poisbeau P, Rotonda C, Tarquinio C.   +5 more
europepmc   +1 more source

Neglected diagnostics  [PDF]

Nature Methods, 2007
openaire   +2 more sources