Results 101 to 110 of about 458,223 (349)

Government action needed to step up research and development for world’s most neglected diseases [PDF]

, 2005
Bernard Pécoul
openalex   +1 more source

Experience and Challenges from Clinical Trials with Malaria Vaccines in Africa. [PDF]

, 2013
Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades ...
A Nyika, A Olotu, A Roca-Feltrer, AA Holder, AJ Luty, AVS Hill, B Moonen, Bernhards Ogutu, Beverly Msambichaka, BF Chumpitazi, Bouharoun-Tayoun H Druilhe P, C Guinovart, C Roussilhon, C Swysen, DA Chokshi, DA Diallo, E Peduzzi, Eakin, Bull SS, Riley K,Reeves MM, Gutierrez S, McLaughlin P, FM Ndungu, FM Ndungu, FM Thompson, Grace Mwangoka, H Bouharoun-Tayoun, HL Smits, I Nebie, J Schantz-Dunn, JL Sarthou, K Miura, K Shubis, KE Kester, KE Kester, KP Asante, L Schwartz, M Roestenberg, M Roestenberg, Marcel Tanner, Maxmillian Mpina, MP Girad, Nahya Salim, NC Iriemenam, NJ White, OK Doumbo, PG Cech, PL Alonso, PL Alonso, PL Alonso, PO Tindana, R Chilengi, RR Taylor, S Casares, Salim Abdulla, Seif Shekalaghe, Shubis Kafuruki, SJ Rogerson, SL Hoffman, ST Agnandji, ST Agnandji, T Smith, T Smith, T Smith, TA Lang, The malERA Consultative Group on Vaccines, Tutu Mzee, V Gardette, V Moorthy, WHO, WHO, YP Shi   +67 more
core   +3 more sources

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Correction: Weather Regulates Location, Timing, and Intensity of Dengue Virus Transmission between Humans and Mosquitoes. [PDF]

PLoS Neglected Tropical Diseases, 2015
PLOS Neglected Tropical Diseases Staff
doaj   +1 more source

New hope for neglected diseases [PDF]

, 2002
Victoria Hale
openalex   +1 more source

Ethiopia schistosomiasis and soil-transmitted helminthes control programme: progress and prospects [PDF]

, 2017
Schistosomiasis and soil-transmitted helminthes are among seventeen WHO prioritized neglected tropical diseases that infect humans. These parasitic infections can be treated using single-dose and safe drugs.
Deribe, Kebede, Ejigu, Ephrem, Kebede, Biruck, Mekete, Kalkidan, Mengistu, Birhan, Negussu, Nebiyu, Sileshi, Mesfin, Tadesse, Gemechu   +7 more
core  

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source