Results 201 to 210 of about 1,125,330 (386)

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Halting hyaluronidase hopping to maintain the integrity of Medicare drug price negotiation. [PDF]

J Manag Care Spec Pharm
Kim J, Kesselheim AS, Rome BN.
europepmc   +1 more source

Participatory flood modelling for negotiation and planning in urban informal settlements [PDF]

, 2019
Joe Mulligan, Vera Bukachi, Rodoula Gregoriou, Nilani Venn, Duncan Ker-Reid, Alan Travers, Benard Juma, Luke Olang   +7 more
openalex   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

From leisure motivation to recreation specialization: a study on the psychological mechanism of sustainable participation of ice and snow sports participants. [PDF]

Front Psychol
Liang Y, Li J, Wang Z.
europepmc   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Consequences of Canada's Drug Agency Reimbursement Recommendations for New Medicines and Pan-Canadian Pharmaceutical Alliance Price Negotiations on Patient Access. [PDF]

Clinicoecon Outcomes Res
Rawson NSB.
europepmc   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

High‐Rate Cross‐Channel Entanglement Swapping Between Independent On‐Chip Sources

Advanced Science, EarlyView.
To interconnect individual chip‐based quantum sources, high‐performance entanglement swapping is indispensable. Here, using low‐loss silicon chips with waveguide structure and frequency‐offset pumps, this work demonstrates high‐rate cross‐channel entanglement swapping.
Haoyang Wang, Huihong Yuan, Qiang Zeng, Lai Zhou, Haiqiang Ma, Zhiliang Yuan   +5 more
wiley   +1 more source

Health diplomacy training, pedagogical approaches, and skills assessment: a scoping review. [PDF]

Front Public Health
Joshi A, Magana L, Jha N, Otok R, Kapologwe NA, Sampaio LA, Kastrup E, Amde W, Surenthirakumaran R, El-Mohandes A, Reis R, Kim SY, Kane C, Mackey TK, Yotive W, Barros H, Kaledine R, Figueras J, Brown MD.   +18 more
europepmc   +1 more source