Results 111 to 120 of about 195,715 (304)

THE CHALLENGES OF THE NEXT EUROPEAN UNION ENLARGEMENT [PDF]

Challenges of the Knowledge Society, 2011
After nearly six decades of evolution marked by five successive waves of enlargement, today's EU with 27 Member States, totaling a population of close 500 million people, is a prosperous and powerful entity that exercises a growing influence on the ...
DAN VATAMAN
doaj  

Disconnections in US and EU Agricultural Policy and Trade Negotiations: A Transaction Cost Politics Approach [PDF]

This article investigates aspects of the institutions and decision making processes in the United States and the European Union that affect the coordination of domestic farm programs and trade negotiations for agriculture in each entity.
Young, Linda M., Hansen, Kathleen C.
core  

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Free Trade Agreements Between the EU and New Zealand and the EU and Australia: An Assessment of Labour Law Provisions

Acta Universitatis Lodziensis Folia Iuridica
In the first main part of the article, the author researches labour provisions included in the EU–New Zealand free trade agreement (FTA) of 2022. She explains why this FTA shall be perceived as a new, fifth generation FTA and what are the key changes the
Aneta Tyc
doaj   +1 more source

Intra-institutional coordination and inter-institutional negotiations: The creation of the European External Action Service (EEAS) [PDF]

Analyses of the rising capacity for coordination within the Secretariats-General of the European Commission and Council have concentrated on their effects within these respective institutions.
Murdoch, Zuzana
core  

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Issue Linkage and Issue Tie-in in Multilateral Negotiations [PDF]

We describe a model of international, multidimensional policy coordination where countries can enter into selective and separate agreements with different partners along different policy dimensions.
Carlo Perroni, Paola Conconi
core  

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

The Organization as Negotiator

, 2017
Editors’ Note: The authors discuss the surprising shortage of researchon how organizations negotiate or plan to negotiate, when the work isconsidered on a broader than individual level. They contrast this withevidence that certain organizations have profited enormously, and evenbecome dominant players in their markets, largely by adopting andenforcing ...
Borbély, Adrian, Caputo, Andrea
openaire   +2 more sources