Results 101 to 110 of about 449,184 (311)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Soerens, Tim, 2020. Everywhere You Look: Discovering the Church Right Where You Are
Ecclesial Futures, 2021 Elaine A. Heath
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Journal of Photochemistry and PhotobiologyCancer remains one of the leading causes of global mortality due to the uncontrolled proliferation of malignant cells. Although conventional treatments such as chemotherapy and immunotherapy have advanced, their associated adverse effects may compromise ...
Leandro de Oliveira Porfírio +6 more
doaj +1 more source
Experimental Analysis of Neighborhood Effects on Youth [PDF]
neighborhood, real experiment, multiple ...
Jeffrey R. Kling, B. Jeffrey Liebman
core
Beaverdale Neighborhood Charter Plan Update [PDF]
, 2014 In September of 2011, the Beaverdale Neighborhood Association (BNA) filed an application to participate in the pilot Charter Neighborhood Program in order to update its original plan that was approved in 1991 with new goals for the future. On November 21,
Rongerude, Jane +3 more
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Neighborhood Effects and Housing [PDF]
This chapter presents a number of approaches that economists have used in studying neighborhood effects in housing markets. It emphasizes how individuals in effect choose neighborhood effects, or more generally social interactions, via their location ...
Yannis M. Ioannides
core
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Characterization of neighborhood operators based on neighborhood relationships
Journal of Intelligent SystemsAbstract Neighborhood relationships play a pivotal role in rough set theory, addressing the limitations of equivalence relations. This article focuses on defining upper and lower approximation operators using neighborhood relationships and exploring their properties in terms of serialization, inverse serialization, reflexivity ...
Caixin, Wei +3 more
openaire +3 more sources