Results 171 to 180 of about 436,057 (310)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Independent Associations of Food Insecurity and Neighborhood Deprivation: Independent Associations with Incident Metabolic Dysfunction-Associated Steatotic Liver Disease in a Diverse U.S. Cohort. [PDF]

Nutrients
Eun Y, Thearle MS, Kim JH, Trousdale RK, Culpepper-Morgan J.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Individual and Contextual Socioeconomic Position on Type 2 Diabetes Risk in LMICs: A Multilevel Analysis. [PDF]

Ann N Y Acad Sci
Fahimi R, Alrubayyi A, Hassan M, Barber TM, Uthman OA.   +4 more
europepmc   +1 more source

Ironville Neighborhood Playground Sandbox

, 1909
Women and children pose for a portrait sitting in a sandbox located in the rear of the Ironville Neighborhood Park at Lincoln Place Park in September of 1909. In addition to the playground, the Park House and Neighborhood Cottage are also visible.

core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Adolescent loneliness and precarious employment in young adulthood: The moderating role of school attachment. [PDF]

J Res Adolesc
Son H, Song K, Kim J.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Neighborhood greenspace and brain imaging outcomes in older adults without dementia from three US Alzheimer's Disease Research Centers. [PDF]

Health Place
Besser LM, Mitsova D, Carmichael O, Bateman JR, Lovasi GS, Tourelle M, Galvin JE, Chang LC, DeCarli C, Morris JC, Meyer OL.   +10 more
europepmc   +1 more source

Ironville Neighborhood Playground

, 1909
Women and children pose for a portrait sitting on a spinner located in the Ironville Neighborhood Park at Lincoln Place Park around1909. In addition to the playground, the Park House and Neighborhood Cottage are also visible.

core