Results 171 to 180 of about 359,204 (312)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Ironville Neighborhood Playground Sandbox
, 1909 Women and children pose for a portrait sitting in a sandbox located in the rear of the Ironville Neighborhood Park at Lincoln Place Park in September of 1909. In addition to the playground, the Park House and Neighborhood Cottage are also visible.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Neighborhood Frequency Effects in Late Bilingual Phonological Neighborhoods
Acta PsychologicaThe bilingual mental lexicon is understood as a unified system containing word forms from multiple languages. Previous studies have described how cross-language phonological similarity influences bilingual lexical processing, demonstrating that lexical activation spreads both within and across languages at the segmental level. The significance of cross-
openaire +2 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Neighborhood Socioeconomic Disadvantage, Residential Stability, and Perceptions of Social Support among New Mothers [PDF]
Neighborhoods are important sites for the formation and development of social ties. In theory, living in a disadvantaged neighborhood may be associated with lacking social support.
Kristin Turney, Kristen Harknett
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Neighborhood Satisfaction in Modern and Old Neighborhoods in Ýstanbul [PDF]
There is growing interest among academics and policy makers in both Turkey and abroad to monitor social progress. As a result of this, much activity is focused on measuring quality of neighborhood life, via the development and implementation of ...
Emine Ümran Topçu
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Urban Poverty and Health in Developing Countries: Household and Neighborhood Effects [PDF]
In the U.S. and other high-income countries, where most of the population lives in urban areas, there is intense scholarly and program interest in the effects of household and neighborhood living standards on health.
Paul C. Hewett, Mark R. Montgomery
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