Results 171 to 180 of about 449,184 (311)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mediation of physical activity and sedentary behavior on the relationship between neighborhood greenness and cardiovascular outcomes. [PDF]

Public Health Pract (Oxf)
Yang D, Lee JM, Shen J, Wen X, Kim J.
europepmc   +1 more source

Bancroft - Upton - Monroe neighborhood : neighborhood analysis

This report was published by the Toledo Lucas County Plan Commissions Neighborhood Planning Program in 1981. It details population characteristics, housing, land use, zoning, and transportation of the Bancroft-Upton-Monroe neighborhood in Toledo ...
Toledo Lucas County Plan Commissions. Neighborhood Planning Program
core  

Urban Poverty and Health in Developing Countries: Household and Neighborhood Effects [PDF]

In the U.S. and other high-income countries, where most of the population lives in urban areas, there is intense scholarly and program interest in the effects of household and neighborhood living standards on health.
Paul C. Hewett, Mark R. Montgomery
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Tigard neighborhood trails plan

, 2009
"The Tigard neighborhood trails plan seeks to improve opportunities for walking, bicycling and using transit in the City of Tigard by creating and formalizing short, unofficial neighborhood trail connections to provide for more direct travel.

core  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

BitterBuster: A virtual world for understanding naturalistic patch foraging. [PDF]

PLoS One
Kasarda JP, Bahuguna J, Zhang A, Tong H, Tan Y, Wang R, Tarr MJ, Verstynen T.   +7 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Family and neighborhood environments in adolescence and subsequent mortality. [PDF]

J Gerontol B Psychol Sci Soc Sci
Lawrence EM, Rogers RG, Loehr LR, Whitsel EA.   +3 more
europepmc   +1 more source