Results 151 to 160 of about 436,057 (310)
Neighborhood Effects: Accomplishments and Looking Beyond Them [PDF]
The paper addresses the empirical significance of the social context in economic decisions. Decisions of individuals who share spatial and social milieus are likely to be interdependent, and econometric identification of social effects poses intricate ...
Yannis M. Ioannides, Giorgio Topa
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Fall 2013 Know Your Neighborhood
, 2013 Recitation - Know Your NeighborhoodA recitation guide for lecture 4 "Know Your Neighborhood." Includes stated objectives - what is journalism and who is a journalist, lecture recap, news neighborhood taxonomy chart assignment, YouTube video assignment ...
Stony Brook University. School of Journalism. Center for News Literacy.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Capitol East Neighborhood Charter Plan Update [PDF]
, 2014 The first Capitol East Neighborhood Action Plan, completed in December of 1990, was successful in achieving its goals. Neighborhood accomplishments borne of the first plan include the following: the construction of a new elementary school (Capitol View);
Blumstein, Anna +7 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Beyond Treatment Effects: Estimating the Relationship Between Neighborhood Poverty and Individual Outcomes in the MTO Experiment [PDF]
neighborhood effects, social ...
Lawrence Katz, Jeffrey R. Kling
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Neighborhood Satisfaction in Modern and Old Neighborhoods in Ýstanbul [PDF]
There is growing interest among academics and policy makers in both Turkey and abroad to monitor social progress. As a result of this, much activity is focused on measuring quality of neighborhood life, via the development and implementation of ...
Emine Ümran Topçu
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