Results 131 to 140 of about 436,057 (310)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Poverty is the Barrier.

open access: yes, 1988
Neighborhood Employment Network, City of Minneapolis, and the Center for Urban and Regional Affairs, University of Minnesota.Neighborhood Employment Network. (1988). Poverty is the Barrier..
Neighborhood Employment Network
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Identifying Individual and Group Effects in the Presence of Sorting: A Neighborhood Effects Application [PDF]

open access: yes
Researchers have long recognized that the non-random sorting of individuals into groups generates correlation between individual and group attributes that is likely to bias naïve estimates of both individual and group effects.
Patrick Bayer, Stephen L. Ross
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Urban Heat Island Research from 2015 to 2024: A Bibliometric Analysis

open access: yesChinese Journal of Urban and Environmental Studies
This study presents a bibliometric analysis of urban heat island (UHI) research published between 2015 and 2024, based on a dataset of 5,144 publications.
Halil DUYMUS
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

A One-Year Retrospective Observational Study of an Occupational Medicine Outpatient Clinic in a City Hospital

open access: yesAnnals of Global Health
Background: Occupational diseases (ODs) remain a major public health concern. Despite advances in occupational health (OH), many workers remain at risk due to insufficient preventive measures and limited access to specialized care.
Yusuf Samir Hasanli
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Neighborhood Effects in Spatial Housing Value Models The Case of the Metropolitan Area of Paris (1999). [PDF]

open access: yes
In hedonic housing models, the spatial dimension of housing values are traditionally processed by the impact of neighborhood variables and accessibility variables.
Catherine Baumont and Diègo Legros
core   +2 more sources

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