Results 141 to 150 of about 1,455,539 (349)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

California's neighborhood [PDF]

California ; Federal Reserve District, 12th ; Regional economics ; West (U.S.)
Brian Cromwell
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Childhood Family Income and Adult Cardiovascular Health: Indirect Effects Through Childhood Neighborhood Socioeconomic Advantages and Disadvantages in a Prospective Sample of Young Men

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Childhood family income may impact men's cardiovascular health (CVH), partly through exposure to neighborhood advantages and disadvantages experienced across childhood.
Emily J. Jones, Portia Miller, Brianna N. Natale, Tess Dupree, Sydney Damon, Anna L. Marsland, Daniel S. Shaw, Elizabeth Votruba‐Drzal   +7 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Influence of social networks and environmental factors on older adults’ regular walking

Frontiers in Public Health
IntroductionFew studies have confirmed the influence of social networks and environmental factors on the regular walking of older adults in the community.
Hwajun Kim, Young Ko, Young Ko
doaj   +1 more source

Project on Human Development in Chicago Neighborhoods (PHDCN): Physical Development Scale, Wave 2, 1997-2000

, 1997
Felton J. Earls, Jeanne Brooks‐Gunn, Stephen W. Raudenbush, Robert J. Sampson   +3 more
openalex   +1 more source

Latino Neighborhoods and Latino Neighborhood Poverty

Journal of Urban Affairs, 1997
To present a national socioeconomic portrayal of Latino neighborhoods, this study examines 1980 and 1990 census tracts that are at least 50 percent Latino. It investigates the determinants of poverty rates and transitions into and out of poverty concentration. A special focus in this analysis is the relationship between immigration and poverty.
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source