Results 211 to 220 of about 436,057 (310)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Association and Interaction of Neighborhood Environment and Social Factors With Blood Glucose Among Adult Residents: A Cross-Sectional Study. [PDF]

Health Sci Rep
Zhang XJ, Xianyu Y, He T, Zhang G, Cui J, Cheng YX, Liu YJ, Chen J, Liu Q, Luo D, Wang XQ, Yang BX, Zou H.   +12 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Neighborhood socioeconomic status and adolescent brain responses to peer feedback: Testing relationships with negative and positive affect assessed outside of the lab. [PDF]

Dev Psychopathol
Rappaport BI, Glazer JE, Letkiewicz AM, Li LY, McGregor MM, Sarkas SE, Sritharan A, Massac L, Durham K, Auerbach RP, Shankman SA.   +10 more
europepmc   +1 more source

Feed the neighborhood : a recipe for neighborhood rejuvenation

, 2018
There are neighborhoods right in the heart of a city that seem dead and forgotten. The inhabitants of the city steer clear of these neighborhoods. I believe many people perceive these places to be beyond repair. Yet, there are a few individuals who have seen potential in the forgotten neighborhood and were able to revive them. In most cases they did it
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Beyond Wait Times: Neighborhood Income Distribution Among Emergency Department Visits Assigned a Leave-Without-Being-Seen Disposition. [PDF]

Cureus
O'Leary RH, Adams H, McDougall P, Atkinson P, Chandra K, McGraw M.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Spaces that move children: The role of the physical environment in developing motor competence and physical literacy. [PDF]

PLoS One
Molina-García J, García-Massó X, Queralt A, Ortega-Benavent N, Menescardi C, Estevan I.   +5 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source