Results 241 to 250 of about 449,184 (311)

Stepwise multi-scale reconstruction of cell spatial organization from single-cell RNA sequencing data with Cell2space. [PDF]

Brief Bioinform
Pan J, Guan Q, Sun D.
europepmc   +1 more source

Revisiting the neighborhood definition in view of the 15-minute neighborhood and sustainable neighborhood concepts

Cities
Mahsa Khatibi, Khairul Anwar Mohamed Khaidzir, Sharifah Salwa Syed Mahdzar, Ayyoob Sharifi   +3 more
openaire   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Association Between Changes in Perceived Neighborhood and Cognitive Performance Within Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Black Adults. [PDF]

Int J Environ Res Public Health
Allan AC, Gamaldo AA, Thorpe RJ, Roberts JD, Evans MK, Zonderman AB.   +5 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Older adults in more disadvantaged neighborhoods exhibit brain vascular dysfunction. [PDF]

Cereb Circ Cogn Behav
Law KW, Engstrom AC, Lohman T, Quiring M, Kapoor A, Alitin JPM, Wang DJJ, Gaubert A, Rodgers K, Head E, Valencia CI, Joyce JL, Ferrer F, Nation DA.   +13 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Gun Violence Exposure and the Perceived Need to Carry a Firearm: The Role of Community Violence Intervention Awareness. [PDF]

J Urban Health
Oliphant SN, Bhatia S, Bishai J, Paruk JK, Lee DB, Semenza DC, Papachristos AV, Heinze JE.   +7 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source