Results 161 to 170 of about 12,304,496 (201)

Neisseria meningitidis serogroup B vaccine development

Microbial Pathogenesis, 2013
Neisseria meningitidis is an air-borne, gram-negative pathogen that actively invades its human host leading to the development of life-threatening pathologies. As one of the leading causes of death in the world, during an epidemic period N. meningitidis can be responsible for nearly 1000 new infections per 100,000 individuals.
Nicole M, Caesar, Kenneth A, Myers, Xin, Fan   +2 more
exaly   +3 more sources

Proteome analysis of Neisseria meningitidis serogroup A

PROTEOMICS, 2004
AbstractNeisseria meningitidis is an encapsulated Gram‐negative bacterium responsible for significant morbidity and mortality worldwide. Meningococci are opportunistic pathogens, carried in the nasopharynx of approximately 10% of asymptomatic adults. Occasionally they enter the bloodstream to cause septicaemia and meningitis.
Bernardini G, Renzone G, Comanducci M, Mini R, Arena S, D'Ambrosio C, Bambini S, Trabalzini L, Grandi G, Martelli P, Achtman M, Scaloni A, Ratti G, Santucci A   +13 more
openaire   +7 more sources

Monocyte phagocytosis of opsonized Neisseria meningitidis serogroup B

APMIS, 1992
The chemiluminescence (CL) was examined when peripheral blood monocytes were incubated with opsonized Neisseria meningitidis, serogroup B, serotype 15:P1.16 or serotype 2a:P1.2. The monocytes were separated from a mononuclear cell suspension by an immunomagnetic negative selection technique using magnetic polystyrene microspheres coated with monoclonal
H, Sjursen, V, Lehmann, A, Naess, T, Hervig, R W, Flø, B, Maehle, A I, Halstensen, L O, Frøholm   +7 more
openaire   +2 more sources

Molecular Mimetics ofNeisseria meningitidisSerogroup B Polysaccharide

International Reviews of Immunology, 2001
Strains of Neisseria meningitidis serogroup B (NmB) are an important cause of meningitis and sepsis. Efforts to develop a NmB vaccine have been hampered by poor immunogenicity of the polysaccharide capsule, which cross-reacts with host polysialic acid, and the danger of eliciting autoantibodies.
G R, Moe, D M, Granoff
openaire   +2 more sources

Reverse Vaccinology and Vaccines for Serogroup B Neisseria meningitidis

2007
Whole genome sequence data are increasingly available for a wide range of human pathogens. The use of bioinformatic tools allows the comprehensive in silico screening of genome data for surface-expressed proteins, in order to identify candidate vaccine antigens.
Dominic F, Kelly, Rino, Rappuoli
openaire   +2 more sources

Vaccination against serogroup B Neisseria meningitidis: Perceptions and attitudes of parents

Vaccine, 2015
A vaccine against serogroup B Neisseria meningitidis, major cause of bacterial meningitis in children and adults, has recently been developed. In a context of an increasing parental mistrust against vaccinations, understanding the reason for their choices is crucial in order to improve immunization coverage.
Le Ngoc Tho, Sandra, Ader, Florence, Ferry, Tristan, Floret, Daniel, Arnal, Maximilien, Fargeas, Simone, Chidiac, Christian, Valour, Florent   +7 more
openaire   +4 more sources

A Challenge in Vaccine Development —Neisseria meningitidisSerogroup B

New England Journal of Medicine, 2016
Proving the clinical efficacy of Neisseria meningitidis serogroup B (MenB) vaccines has been difficult. There is substantial genetic (and corresponding antigenic) diversity, and serogroup B meningococcal disease is both uncommon and in decline in countries where the burden is well understood.
openaire   +2 more sources

Neisseria meningitidis Serogroup B Polysialyltransferase: Insights into Substrate Binding

ChemBioChem, 2010
On the loose: We report an STD NMR spectroscopic study of the polysialyltransferase from Neisseria meningitidis serogroup B (NmB-polyST). The spectra reveal that the cytosine and ribose moiety receive more saturation than the sialic acid residue of CMP-Neu5Ac.
Boehm, Raphael, Freiberger, Friedrich, Stummeyer, Katharina, Gerardy-Schahn, Rita, von Itzstein, Mark, Haselhorst, Thomas   +5 more
openaire   +3 more sources

Genotypic characterization of Neisseria meningitidis serogroup B strains circulating in China

Journal of Infection, 2008
In China, comparatively little research has been directed at serogroup B meningococci, which are mainly isolated from healthy individuals. We attempted to study the genotypic characterization of Neisseria meningitidis serogroup B strains.We analyzed 150 N.
Li, Yang, Zhujun, Shao, Xiaobing, Zhang, Li, Xu, Junping, Peng, Xingye, Xu, Xiaofeng, Liang, Yipeng, Qi, Qi, Jin   +8 more
openaire   +2 more sources

Neisseria meningitidis serogroup B peritonitis associated with continuous ambulatory peritoneal dialysis

European Journal of Clinical Microbiology & Infectious Diseases, 1998
A case of Neisseria meningitidis peritonitis in a 41-year-old female undergoing continuous ambulatory peritoneal dialysis for end-stage renal failure due to insulin-dependent diabetes mellitus is reported. The bacterial strain was serosubtyped as 4:P1.15, a rarely encountered type.
G, Conrads, G, Haase, N, Schnitzler, I, Ehrhard, H, Schmitt   +4 more
openaire   +2 more sources