Results 91 to 100 of about 93,598 (305)

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]

, 2014
Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L, Ehsaan, M, Heap, JT, Knox, R, Kubiak, AM, Kuehne, SA, Lambin, P, Mellaert, LV, Minton, NP, Paesmans, K, Theys, J   +10 more
core   +4 more sources

Bacterial antigen detection in cerebrospinal fluid by the latex agglutination test Detecção de antígenos bacterianos no líquido cefalorraquidiano através do teste de aglutinação de latex

Revista do Instituto de Medicina Tropical de São Paulo, 1995
Eighty purulent cerebrospinal fluid (CSF) samples from patients with clinical evidence of meningitis were studied using the Directigen latex agglutination (LA) kit to determine the presence of bacterial antigen in CSF.
Ilka Maria Landgraf, Maria das Graças Adelino Alkmin, Maria de Fátima Paiva Vieira   +2 more
doaj   +1 more source

Population-Based Surveillance of Neisseria meningitidis Antimicrobial Resistance in the United States

Open Forum Infectious Diseases, 2015
Isolates of Neisseria meningitidis collected in 2004, 2008, 2010, and 2011 from an active population-based surveillance system in the United States were tested for susceptibility to antimicrobials used for treatment and chemoprophylaxis of meningococcal ...
B. Harcourt, Raydel D. Anderson, Henry M. Wu, A. Cohn, Jessica R Macneil, T. Taylor, Xin Wang, T. Clark, Nancy E. Messonnier, L. Mayer   +9 more
semanticscholar   +1 more source

Discovery of RNA‐Targeting Small Molecules: Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
This review explores challenges and future directions in discovering RNA‐targeting small molecules, from analyzing RNA structures and computational design to experimental workflows. It discusses mechanistic strategies like splicing modulation and RNA degradation, alongside advanced tools (deep learning, docking, and validation) to accelerate drug ...
Zhengguo Cai, Hongli Ma, Fengcan Ye, Dingwei Lei, Zhenfeng Deng, Yongge Li, Ruichu Gu, Han Wen   +7 more
wiley   +1 more source

Cases of Neisseria meningitidis in Greece

Eurosurveillance, 1997
In Greece, Neisseria meningitidis appears as sporadic cases with some seasonal local outbreaks. The notification of meningococcal disease to the local health authorities and the Ministry of Health is mandatory.
Georgina Tzanakaki, N Vakalis, A Velonaki, Jenny Kremastinou   +3 more
openaire   +3 more sources

Emergence and genomic diversification of a virulent serogroup W:ST-2881(CC175) Neisseria meningitidis clone in the African meningitis belt. [PDF]

, 2017
Countries of the African 'meningitis belt' are susceptible to meningococcal meningitis outbreaks. While in the past major epidemics have been primarily caused by serogroup A meningococci, W strains are currently responsible for most of the cases.
Abdul Sater, Mohamad R, Bentley, Stephen D, Dangy, Jean-Pierre, Hamid, Abdul-Wahab M, Harris, Simon R, Hauser, Julia, Hodgson, Abraham, Junghanss, Thomas, Lamelas, Araceli, Parkhill, Julian, Pluschke, Gerd, Röltgen, Katharina, Sie, Ali   +12 more
core   +1 more source

Neisseria meningitidis ST-11 Clonal Complex, Chile 2012

Emerging Infectious Diseases, 2015
Serogroup W Neisseria meningitidis was the main cause of invasive meningococcal disease in Chile during 2012. The case-fatality rate for this disease was higher than in previous years. Genotyping of meningococci isolated from case-patients identified the
P. Araya, Jorge Fernández, Felipe Del Canto, M. Seoane, A. Ibarz-Pavón, G. Barra, P. Pidal, Janepsy Díaz, J. Hormázabal, M. Valenzuela   +9 more
semanticscholar   +1 more source

Trends in Paediatric Viral Meningitis and Encephalitis With Unconfirmed Aetiology: A Spanish Population‐Based Study, 2016–2020

Acta Paediatrica, Volume 114, Issue 9, Page 2298-2305, September 2025.
ABSTRACT Aim The prevalence of meningitis and encephalitis of unknown aetiology in Spanish children has not been specifically documented before. The aim of this study is to describe the epidemiology and trends of these clinical conditions between 2016 and 2020.
Marina Pons‐Espinal, Noemi López‐Perea, Josefa Masa‐Calles, Carmen Muñoz‐Almagro, David Tarragó, Cristian Launes   +5 more
wiley   +1 more source

A critical role for ATF2 transcription factor in the regulation of E-selectin expression in response to non-endotoxin components of Neisseria meningitidis [PDF]

, 2015
Vascular injury is a serious complication of sepsis due to the gram-negative bacterium Neisseria meningitidis. One of the critical early steps in initiating this injury is via the interaction of leucocytes, particularly neutrophils, with adhesion ...
Bajaj-Elliott, M, Dixon, GL, Dusart, PJ, Hart, SL, Jacobsen, MC, Klein, NJ, Kotowicz, K   +6 more
core   +1 more source