Results 181 to 190 of about 209,106 (262)

Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Glossotonsillar Sulcus Involvement Conveys an Unfavorable Oncological Outcome

Head &Neck, EarlyView.
ABSTRACT Background Transoral robotic surgery (TORS) is widely used in management of early‐stage primary oropharyngeal squamous cell carcinoma (OPSCC). Tumors involving the glossotonsillar sulcus (GTS) are hypothesized to confer worse oncological outcomes compared to those situated in the rest of the oropharynx, with a paucity of evidence to support ...
Johan S. Nilsson, John C. Hardman, James Tsimiklis, Bora Jeong, Maryam Khan, Jonathan Daniel, Giri Krishnan, Andrew Foreman, Suren Krishnan, John‐Charles Hodge   +9 more
wiley   +1 more source

Efficacy and Safety of Neoadjuvant Chemotherapy Followed by CDK4/6 Inhibitors Plus Endocrine Therapy in Patients With HR-Positive, HER2-Negative Breast Cancer: A Retrospective Single-Centre Cohort Analysis. [PDF]

Cancer Med
Dong X, Li F, Yuan Y, Song H, Wang Y, Hao Y, Dong Y, Wang T, Bian L, Zhang S, Li J.   +10 more
europepmc   +1 more source

Neoadjuvant Cemiplimab for Resectable Locoregionally Advanced Cutaneous Squamous Cell Carcinoma: A Case Series

Head &Neck, EarlyView.
ABSTRACT Introduction A Phase II trial demonstrated that neoadjuvant cemiplimab was associated with pathologic complete response (pCR) in 51% of patients with locoregionally advanced cutaneous squamous cell carcinoma (cuSCC). We evaluated real‐world radiographic and pathologic responses to neoadjuvant cemiplimab and assessed radiologic–pathologic ...
Whitney Jin, Ryan K. Rigsby, Kim Ely, Austin Hoke, Robert Sinard, Kyle Mannion, Jill Gilbert, Lindsay Mundy, Alexander Langerman, Sarah Rohde, Barbara Murphy, Eben Rosenthal, Mitra Mehrad, Michael C. Topf, Jennifer H. Choe   +14 more
wiley   +1 more source

Complete Pathologic Response to Neoadjuvant Pembrolizumab Captured on Intraoperative PET/CT: A Case Report and Exploratory Analysis

Head &Neck, EarlyView.
ABSTRACT Background Neoadjuvant immunotherapy is an emerging treatment for patients with head and neck cancer. Given the heterogeneity of response, novel methods of intraoperative tumor and margin assessment warrant investigation. Methods A 55‐year‐old male presented with a cT3N2c supraglottic squamous cell carcinoma with a combined positive score of 5.
Joaquin Austerlitz, Andreja Radevic, Ashtyn McAdoo, Kyrionna Golliday, Cassie Pan, Annie Moroco, Spencer Roark, Michael C. Topf   +7 more
wiley   +1 more source

Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): an open-label, single-arm, phase 2 study. [PDF]

J Immunother Cancer
Wei Z, Chen H, Wang D, Li L, Pei Y, Yang H, Wang F, Jin J, Luo Y, Chen F, Liu J, Peng X.   +11 more
europepmc   +1 more source

Complication Rates Associated With Evolving Practice Patterns in Vasopressor Use and Fluid Administration for Oral Cavity Cancer Free Flap Reconstruction

Head &Neck, EarlyView.
ABSTRACT Background The safety of vasopressors for managing intraoperative hypotension remains debated. This study evaluated complications associated with vasopressor use and fluid administration in oral cavity cancer free flap surgery. Methods Retrospective review of 826 patients who received oral cavity cancer free flap reconstruction from 2008 to ...
Harrison Gao, Nuwan Dharmawardana, Alex O. Esemezie, Hedyeh Ziai, Philopateer Ataalla, Natalie Weisbrod, Konrado Deutsch, Stuart A. McCluskey, Danny Enepekides, Kevin M. Higgins, Antoine Eskander, John R. de Almeida, David P. Goldstein, Ralph W. Gilbert, Jonathan C. Irish, Dale H. Brown, Christopher M. K. L. Yao, Christopher W. Noel, Sharon Tzelnick   +18 more
wiley   +1 more source

Surgical Complexity and Perioperative Feasibility Following Neoadjuvant Chemotherapy, Chemoradiotherapy, or Chemoimmunotherapy in Stage II-III Non-Small Cell Lung Cancer: A Retrospective Single-Institution Study. [PDF]

Cancers (Basel)
Sakai H, Hatakeyama T, Homma T, Otsubo K, Kakizaki N, Marushima H, Kojima K, Morikawa K, Furuya N, Mineshita M, Sugiura Y, Koike J, Saji H.   +12 more
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Navigating the immunosuppressive abyss: current hurdles and innovative breakthroughs in neoadjuvant immunotherapy for osteosarcoma. [PDF]

Front Immunol
Chen G, Hu M, Li Z, Yang K, Chen B, Xu T.   +5 more
europepmc   +1 more source

Value of Axillary Palpation and Ultrasound, and Axillary Recurrence in Male Breast Cancer: Results of the Registry Study

International Journal of Cancer, EarlyView.
ABSTRACT Clinical and sonographic examination of breasts and axillae is standard in breast cancer (BC) care. The aim of this study is to highlight the value of axillary ultrasound in identifying axillary recurrences in male BC, which is still little considered in the literature.
Monika Graeser, Susen Bothin, Oleg Gluz, Mathias Warm, Atanas Ignatov, Holm Eggemann   +5 more
wiley   +1 more source