Complete pathological response to neoadjuvant chemoradiotherapy in Crohn's disease-associated fistula adenocarcinoma: a case report. [PDF]
Dahmeni W +12 more
europepmc +1 more source
Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley +1 more source
Identification of neoadjuvant chemoradiotherapy resistance-associated proteins in locally advanced rectal cancer: A pilot study. [PDF]
He JY +13 more
europepmc +1 more source
This study assessed neoadjuvant PD‐1 blockade plus chemotherapy in patients with resectable limited‐stage small cell lung cancer. Peri‐treatment biopsy and surgical samples were analyzed using bulk RNA sequencing and bioinformatics approaches.
Shiyue Wan +14 more
wiley +1 more source
Multivariable Radiomics Model for Predicting Programmed Death-Ligand 1 Expression After Neoadjuvant Chemoradiotherapy in Esophageal Squamous Cell Carcinoma. [PDF]
Do Jung H +6 more
europepmc +1 more source
This study comprehensively characterizes the long‐term prognosis and immunotranscriptomic landscape associated with different tumor regression grades (TRGs) in esophageal squamous cell carcinoma (ESCC) following neoadjuvant chemoradiotherapy. By integrating bulk RNA‐seq, single‐cell transcriptomics, and multiplexed immunohistochemistry, we demonstrate ...
Jianye Yuan +13 more
wiley +1 more source
Association between surgical timing and postoperative outcome in patients with residual esophageal cancer after neoadjuvant chemoradiotherapy. [PDF]
Kobayashi S +13 more
europepmc +1 more source
The up‐to‐date clinical progress of immune checkpoint inhibitor (ICI) therapy in solid tumors, specifically the combinational regimens between ICIs and other treatment strategies, the mechanisms underlying primary and acquired resistance, and mechanism‐matched strategies to improve clinical outcomes are synthesized in this review.
Qiongyu Zhang, Zhi Qin, Caijuan Guo
wiley +1 more source
Pathological Response of Locally Recurrent Rectal Cancer to Neoadjuvant Chemoradiotherapy. [PDF]
Yokoyama Y +11 more
europepmc +1 more source
Multi‐modal direct LINAC parameter prediction for pancreatic VMAT: An optimization‐free approach
Abstract Background Pancreatic cancer Volumetric Modulated Arc Therapy (VMAT) planning presents a significant dosimetric challenge due to the high‐dose gradients required to spare adjacent, radiosensitive organs at risk (OARs) like the stomach and duodenum. This anatomical complexity has limited the scope of automated planning for this site.
Zixu Guan +5 more
wiley +1 more source

