Results 21 to 30 of about 92,115 (273)

Management of Clinically Involved Lateral Lymph Node Metastasis in Locally Advanced Rectal Cancer: A Radiation Dose Escalation Study

Frontiers in Oncology, 2021
BackgroundPatients with lateral lymph nodes (LLNs) metastasis are not effectively treated with neoadjuvant chemoradiotherapy. This study aimed to compare the efficacy of three neoadjuvant therapeutic regimens, namely, chemotherapy, chemoradiotherapy, and
Xiaolin Pang, Xiaolin Pang, Liang Huang, Liang Huang, Yan Ma, Yan Ma, Zhanzhen Liu, Zhanzhen Liu, Peiyi Xie, Peiyi Xie, Hailing Liu, Hailing Liu, Xiangbo Wan, Xiangbo Wan, Shuai Liu, Shuai Liu, Jian Zheng, Jian Zheng   +17 more
doaj   +1 more source

Survival benefit of adding chemotherapy to intensity modulated radiation in patients with locoregionally advanced nasopharyngeal carcinoma. [PDF]

PLoS ONE, 2013
BACKGROUND:To evaluate the contribution of chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity modulated radiotherapy (IMRT) and to identify the optimal combination treatment strategy.
Xuemei Ji, Conghua Xie, Desheng Hu, Xia Fan, Yajuan Zhou, Yingjie Zheng   +5 more
doaj   +1 more source

Prospective, open, multi-centre phase I/II trial to assess safety and efficacy of neoadjuvant radiochemotherapy with docetaxel and oxaliplatin in patients with adenocarcinoma of the oesophagogastric junction [PDF]

, 2013
Background: This phase I/II-trial assessed the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of neoadjuvant radiochemotherapy (RCT) with docetaxel and oxaliplatin in patients with locally advanced adenocarcinoma of the oesophagogastric ...
Klautke, Gunther, Galle, Peter R., Brenner, Baruch, Arnold, Dirk, Roessler, Hans-Peter, Thomaidis, Thomas, Schimanski, Carl Christoph, Schmidberger, Heinz, Rödel, Claus, Gockel, Ines, Möhler, Markus, Trarbach, Tanja, Lang, Hauke   +12 more
core   +1 more source

Long-term bowel functional outcomes following anal sphincter-preserving surgery for upper and middle rectal cancer: a single-center longitudinal study [PDF]

Annals of Coloproctology
Purpose Despite advances in neoadjuvant chemoradiotherapy and anal sphincter-preserving surgery for rectal cancer, bowel dysfunction is still unavoidable and negatively affects patients’ quality of life.
Ahmad Sakr, Seung Yoon Yang, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim   +6 more
doaj   +1 more source

Integrating CT-Based Radiomics Analysis With Serum CEA Level to Predict Neoadjuvant Chemoradiotherapy Response in Colorectal Cancer. [PDF]

Kaohsiung J Med Sci
ABSTRACT Response to neoadjuvant chemoradiotherapy (NACRT) in locally advanced colorectal cancer (CRC) varies widely, and accurately identifying poor responders is crucial for guiding timely treatment modification. This study aimed to develop an integrated predictive model combining radiomics derived from routine radiotherapy non‐contrast planning ...
Moi SH, Huang MY, Yang SH, Chen CJ, Jhong YP, Hsu TW, Ke CC.   +6 more
europepmc   +2 more sources

Restaging rectal cancer following neoadjuvant chemoradiotherapy

World Journal of Gastrointestinal Oncology, 2023
Correct tumour restaging is pivotal for identifying the most personalised surgical treatment for patients with locally advanced rectal cancer undergoing neoadjuvant therapy, and works to avoid both poor oncological outcome and overtreatment. Digital rectal examination, endoscopy, and pelvic magnetic resonance imaging are the recommended modalities for ...
Cuicchi, Dajana, Castagna, Giovanni, Cardelli, Stefano, Larotonda, Cristina, Petrello, Benedetta, Poggioli, Gilberto   +5 more
openaire   +2 more sources

Anastomotic leak and neoadjuvant chemoradiotherapy in esophageal cancer [PDF]

Journal of Gastrointestinal Oncology, 2018
Anastomotic leaks (AL) cause significant morbidity after esophagectomy. Most patients receive neoadjuvant chemoradiation (NCR) prior to esophagectomy which has been associated with increase perioperative complications and mortality. We report on a comparison of AL rates in upfront surgical (UFS) and NCR patients.An esophagectomy database was queried ...
Ravi, Shridhar, Caitlin, Takahashi, Jamie, Huston, Matthew P, Doepker, Kenneth L, Meredith   +4 more
openaire   +2 more sources

Phase II trial of preoperative radiochemotherapy with concurrent bevacizumab, capecitabine and oxaliplatin in patients with locally advanced rectal cancer [PDF]

, 2013
Background: Preoperative radiochemotherapy (RCT) with 5-FU or capecitabine is the standard of care for patients with locally advanced rectal cancer (LARC). Preoperative RCT achieves pathological complete response rates (pCR) of 10-15%.
Erik Engel, Engel, Erik, Jürgen Dunst, Florian Würschmidt, Kathrin Dellas, Arnold, Dirk, Dirk Arnold, Michael Richter, Richter, Michael, Rödel, Claus, Thomas Reese, Höhler, Thomas, Thomas Höhler, Claus Rödel, Dellas, Kathrin, Reese, Thomas, Wagner, Wolfgang, Dunst, Jürgen, Würschmidt, Florian, Wolfgang Wagner   +19 more
core   +1 more source

Preoperative (neoadjuvant) chemoradiotherapy in oesophageal cancer

Journal of British Surgery, 2001
Abstract Background Oesophageal cancer carries a poor prognosis. The 5-year survival rate following resection ranges from 10 to 35 per cent. Recent evidence suggests that the addition of non-surgical treatments to surgery may improve resection rates, reduce the risk of recurrence and improve survival.
J I, Geh, A M, Crellin, R, Glynne-Jones
openaire   +2 more sources

Persistent extramural vascular invasion positivity on magnetic resonance imaging after neoadjuvant chemoradiotherapy predicts poor outcome in rectal cancer

Asian Journal of Surgery, 2021
Background: In rectal cancer, extramural vascular invasion (EMVI) is the presence of tumour cells in blood vessels outside the muscular layer, which is associated with poor prognosis.
Osman Serhat Guner, Latif Volkan Tumay
doaj   +1 more source