Results 131 to 140 of about 1,127,554 (354)

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Defining a positive circumferential resection margin in oesophageal cancer and its implications for adjuvant treatment [PDF]

, 2013
A positive circumferential resection margin (CRM) has been associated with a poorer prognosis in oesophageal and oesophagogastric junctional (OGJ) cancer. The College of American Pathologists defines the CRM as positive if tumour cells are present at the
Adam, Adamina, Agresti, American Joint Committee on Cancer, Austin, Courrech Staal, Cox, Deeter, Dexter, Gertler, Griffiths, Harvin, International Union Against Cancer, Jemal, Kaplan, Khan, Law, Mapstone, Medical Research Council Oesophageal Cancer Working Group, Pultrum, Quirke, Reid, Rice, Rosenbaum, Royston, Rubin, Sagar, Saha, Salih, Scheepers, Sujendran, van Hagen, Verhage, Wibe   +33 more
core   +1 more source

Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05).

Japanese Journal of Clinical Oncology, 2019
A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer.
F. Motoi, T. Kosuge, H. Ueno, H. Yamaue, S. Satoi, M. Sho, G. Honda, I. Matsumoto, K. Wada, J. Furuse, Y. Matsuyama, M. Unno   +11 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer [PDF]

, 2014
Background: HAGE protein is a known immunogenic cancer-specific antigen. Methods: The biological, prognostic and predictive values of HAGE expression was studied using immunohistochemistry in three cohorts of patients with BC (n=2147): early primary (EP ...
A G Pockley, AC Wolff, AJ Linley, C Denkert, C Johnson, C Lurquin, CJ Piyathilake, CW Elston, DR Germain, E Dotan, E Yakirevich, EF Velazquez, G Qu, G R Ball, I O Ellis, J Kim, J Roman-Gomez, J Soares, JP Issa, L Harris, L Yang, L Zheng, L Zitvogel, LM McShane, M Clarke, M Otte, ME Hammond, MG Mathieu, MG Mathieu, MO Riener, N Harbeck, NC Wortham, P M Moseley, Q Chen, R C Rees, R Iggo, S E B McArdle, S Gluck, S Shin, S Y T Chan, SE Pinder, SP Adams, T Kurashige, T M A Abdel-Fatah, TM Abdel-Fatah, TM Abdel-Fatah, V Martelange, YI Kim, YT Chen   +48 more
core   +3 more sources

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study [PDF]

, 2018
Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell prolifera-tion. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vit-amin D (25(OH) D) is unknown.
Isenring, Elisabeth, Karapetis, Christos Stelios, Kichenadasse, Ganessan, Kimlin, Michael G, Koczwara, Bogda, Marshall, Skye, Sukumaran, Shawgi, Teleni, Laisa, Walpole, Euan, Woodman, Richard John   +9 more
core   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

The Outcomes of Primary Debulking Surgery and Neoadjuvant Chemotherapy in Advanced Ovarian Cancer

Indonesian Journal of Obstetrics and Gynecology, 2016
Objective: To compare the outcomes and survival rate of primary debulking surgery with neoadjuvant chemotherapy. Method: We selected advanced ovarian cancer patients from medical records.
Dino Rinaldy, Andrijono Andrijono, Bambang Sutrisna   +2 more
doaj   +1 more source

Impact of Radiotherapy, Chemotherapy and Surgery in Multimodal Treatment of Locally Advanced Esophageal Cancer [PDF]

, 2011
Objectives: It was the aim of this study to assess our institutional experience with definitive chemoradiation (CRT) versus induction chemotherapy followed by CRT with or without surgery (C-CRT/S) in esophageal cancer.
Adams R, Annina Lemminger, Bedenne L, Berger B, Bernhard Berger, Claus Belka, Cooper JS, Delcambre C, Denham JW, Herskovic A, Katharina Stahlberg, Malthaner RA, Martin Bleif, Michael Bamberg, Minsky BD, Mizumoto M, Rades D, Sarraf M, Seung SK, Shi XH, Stahl M, Tepper J, Wolf M, Zhang Z   +23 more
core   +1 more source