Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea [PDF]
Stem Cell Reports, 2014 Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population.
M. Lucila Scimone +3 more
doaj +6 more sources
Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro. [PDF]
PLoS Neglected Tropical Diseases, 2016 Fascioliasis (or fasciolosis) is a socioeconomically important parasitic disease caused by liver flukes of the genus Fasciola. Flukicide resistance has exposed the need for new drugs and/or a vaccine for liver fluke control.
Paul McCusker +11 more
doaj +8 more sources
Regeneration in the absence of canonical neoblasts in an early branching flatworm [PDF]
Nature CommunicationsThe remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system.
Ludwik Gąsiorowski +7 more
doaj +7 more sources
Protein Core Fucosylation Regulates Planarian Head Regeneration via Neoblast Proliferation
Frontiers in Cell and Developmental Biology, 2021 Protein glycosylation is an important posttranslational modification that plays a crucial role in cellular function. However, its biological roles in tissue regeneration remain interesting and primarily ambiguous.
Wenjun Wang +14 more
doaj +3 more sources
Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration [PDF]
Protein & Cell, 2018 Regeneration, relying mainly on resident adult stem cells, is widespread. However, the mechanism by which stem cells initiate proliferation during this process in vivo is unclear.
Xiao-Shuai Han +6 more
doaj +4 more sources
Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea [PDF]
BMC Genomics, 2015 The freshwater planarian Schmidtea mediterranea is recognised as a valuable model for research into adult stem cells and regeneration. With the advent of the high-throughput sequencing technologies, it has become feasible to undertake detailed ...
Gustavo Rodríguez-Esteban +4 more
core +5 more sources
Stochastic cell-intrinsic stem cell decisions control colony growth in planarians [PDF]
eLifeStem cells contribute to organismal homeostasis by balancing division, self-renewal, and differentiation. Elucidating the strategies by which stem cells achieve this balance is critical for understanding homeostasis and for addressing pathogenesis ...
Tamar Frankovits +4 more
doaj +4 more sources
Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians [PDF]
HeliyonRegeneration is the ability to accurately regrow missing body parts. The unparalleled regenerative capacity and incredible tissue plasticity of planarians, both resulting from the presence of abundant adult stem cells referred to as neoblasts, offer a ...
Xuhui Chen
doaj +4 more sources
Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica. [PDF]
PLoS PathogensFasciola sp. (liver fluke) are parasitic flatworms that impose a significant burden on the agri-food industry and human health. Immature worms can cause severe damage to the liver as they migrate towards the bile ducts, and yet there is only a single ...
Paul McCusker +10 more
doaj +3 more sources
Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni
eLife, 2013 Schistosomes infect hundreds of millions of people in the developing world. Transmission of these parasites relies on a stem cell-driven, clonal expansion of larvae inside a molluscan intermediate host.
Bo Wang +2 more
doaj +4 more sources