Results 41 to 50 of about 12,237 (200)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Revisitation of the luminance conditions for the occurrence of the achromatic neon color spreading illusion [PDF]

Perception & Psychophysics, 1993
This paper develops the idea (Bressan, 1993) that neon spreading derives from the perceptual scissioning of ordinary assimilation color, a process identical to that occurring with nonillusory colors in phenomenal transparency. It is commonly held that the critical elements in achromatic neon spreading patterns must be of luminance intermediate between ...
openaire   +2 more sources

Isotope effects in the harmonic response from hydrogenlike muonic atoms in strong laser fields

, 2010
High-harmonic generation from hydrogenlike muonic atoms exposed to ultraintense high-frequency laser fields is calculated. Systems of low nuclear charge number Z are considered where a nonrelativistic description applies.
Buervenich, Thomas J., Müller, Carsten, Shahbaz, Atif   +2 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Polymer‐Crosslinking System‐Filler Interactions in Polychloroprene Adhesives: Experimental and Molecular Modeling Insights

Journal of Applied Polymer Science, EarlyView.
The use of polychloroprene is common in elastomeric adhesives. This study highlights the possible substitution of zinc oxide curing systems to a less hazardous metal complex, also evaluating the changes that higher surface area fillers can bring to the adhesive.
Gabriel Bachega Rosa, Sandra Aparecida Coelho Mello, Lucas Sousa Madureira, Silvana Navarro Cassu   +3 more
wiley   +1 more source

Psychophysics of neon color spreading: Chromatic and temporal factors are not limiting

Vision Research
Neon color spreading (NCS) is an illusory color phenomenon that provides a dramatic example of surface completion and filling-in. Numerous studies have varied both spatial and temporal aspects of the neon-generating stimulus to explore variations in the strength of the effect.
Jingyi, He, Ennio, Mingolla, Rhea T, Eskew   +2 more
openaire   +2 more sources

Autowaves in a dc complex plasma confined behind a de Laval nozzle

, 2013
Experiments to explore stability conditions and topology of a dense microparticle cloud supported against gravity by a gas flow were carried out. By using a nozzle shaped glass insert within the glass tube of a dc discharge plasma chamber a weakly ...
Fink, M. A., Höfner, H., Morfill, G. E., Schwabe, M., Thoma, M. H., Thomas, H. M., Zhdanov, S. K.   +6 more
core   +1 more source

A " high 4 He/ 3 He " mantle material detected under the East Pacific Rise (15°4′N) [PDF]

, 2015
International audienceWe investigate in details helium isotope data reported in Mougel et al. (2014) for 14 basaltic samples collected on the East Pacific Rise by submersible (15°4′N) where the ridge interacts with the Mathematician seamounts.
Arnaud Agranier, Berengere Mougel, Dosso L., Gente P., Graham D. W., Manuel Moreira, Todt W.   +6 more
core   +3 more sources