Results 221 to 230 of about 853,397 (306)

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

Angewandte Chemie, EarlyView.
The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia, Giusy Carleo, Zhenni Yang, Francesca Di Matteo, Federica De Rosa, Gerardina Smaldone, Zhao‐Bing Gao, Marco D'Alì, Rita Turcio, Demin Ma, Veronica Di Sarno, Nannan Su, Salvatore Vincenzo Giofrè, Giacomo Pepe, Pietro Campiglia, Alessia Bertamino, Francesco Miceli, Jiangtao Guo, Nunzio Iraci, Carmine Ostacolo, Maurizio Taglialatela   +20 more
wiley   +2 more sources

Authentic and Sustained Family Partnership in Neonatal and Pediatric Research. [PDF]

Pediatrics
Franck LS, Pilon B, Grossbauer L, Stamps T, Moline K, Pawlowski K, Lemmon ME, Chen C, Glass HC, Shellhaas RA, NSR Parent Advisory Panel.   +10 more
europepmc   +1 more source

Evaluation of therapeutic effects of D‐limonene following orchiopexy in the rat model of cryptorchidism

Animal Models and Experimental Medicine, EarlyView.
D‐limonene supplementation enhances testicular recovery following orchiopexy in a rat model of bilateral cryptorchidism. Treatment with D‐limonene reduces oxidative stress (↓MDA, ↑SOD, ↑GPx, ↑TAC), downregulates pro‐apoptotic proteins (↓TNF‐α, ↓BAX, ↓Caspase‐3), and upregulates anti‐apoptotic Bcl‐2 expression.
Arman Norouzi‐Ghalehbala, Mohammadjavad Rezaei‐Varmaziar, Majid Taati, Ali Soleimanzadeh, Abbas Raisi, Farshid Davoodi, Amir Ali Shahbazfar   +6 more
wiley   +1 more source

Developing a prediction model of neonatal pneumonia in patients with gestational diabetes mellitus in primary medical institutions. [PDF]

Front Pediatr
Wu L, Cao Q, Wu J, Liao T, Li L, Yang C.
europepmc   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Impact of real-time respiratory function monitoring on neonatal mask ventilation training: a multicentre simulation-based crossover study. [PDF]

BMJ Paediatr Open
Alrashed L, Bodanese E.
europepmc   +1 more source

Neonatal complications in late-preterm and early-term infants: a systematic review of observational studies. [PDF]

Cochrane Database Syst Rev
Wróblewska-Seniuk K, Arham M, Geist M, Björklund M, Rose CJ, Sibrecht G, Borys F, Soll RF, Fiander M, Bruschettini M, supported by the Cochrane Neonatal Review Group and Cochrane Sweden.   +10 more
europepmc   +1 more source

Evaluation of nursing management strategies for gestational diabetes mellitus and their effects on maternal and neonatal outcomes: A retrospective study. [PDF]

Medicine (Baltimore)
Ni X, Zhang Y, Ni X, Zhou L.
europepmc   +1 more source

Ontogeny of murine bony semicircular canal form

The Anatomical Record, EarlyView.
Abstract The labyrinthine geometry and functional anatomy of the semicircular canals have intrigued scientists for decades, and there has been considerable interest in understanding how these complex structures grow and develop with evidence emerging from human studies that size maturation occurs exceptionally early by comparison with other systems ...
Marcela Cárdenas‐Serna, Nathan Jeffery   +1 more
wiley   +1 more source