Results 61 to 70 of about 759,603 (318)

Neonatal Cholestasis [PDF]

NeoReviews, 2013
Cholestatic jaundice is a common presenting feature of neonatal hepatobiliary and metabolic dysfunction. Any infant who remains jaundiced beyond age 2 to 3 weeks should have the serum bilirubin level fractionated into a conjugated (direct) and unconjugated (indirect) portion. Conjugated hyperbilirubinemia is never physiologic or normal.
Amy G, Feldman, Ronald J, Sokol
openaire   +2 more sources

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Distance to care, facility delivery and early neonatal mortality in Malawi and Zambia. [PDF]

, 2012
BACKGROUND: Globally, approximately 3 million babies die annually within their first month. Access to adequate care at birth is needed to reduce newborn as well as maternal deaths.
Campbell, Oona MR, Lohela, Terhi, Gabrysch, Sabine, Sabine Gabrysch (107728), Oona M R Campbell, Lohela Terhi J., Terhi J Lohela, Oona M. R. Campbell (107725), Lohela, Terhi J, Sabine Gabrysch, Terhi J. Lohela (107721), Campbell Oona M. R., Gabrysch Sabine, Campbell, Oona M. R.   +13 more
core   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Rapid Assessment of the Quality of Neonatal Healthcare in Kilimanjaro Region, Northeast Tanzania. [PDF]

, 2012
While child mortality is declining in Africa there has been no evidence of a comparable reduction in neonatal mortality. The quality of inpatient neonatal care is likely a contributing factor but data from resource limited settings are few. The objective
Mbwele, Bernard, Reddy, Elizabeth, Bernard Mbwele, Elizabeth Reddy, Hugh Reyburn, Reyburn, Hugh   +5 more
core   +1 more source

Neonatal Care [PDF]

, 2012
This up-to-the-minute work is set against the backdrop of remarkable advances in Neonatal care. Including selected updates of contemporary issues concerning basic research and clinical practice, the present book investigates pathogenetic mechanisms ...

core   +4 more sources

Mesenchymal Stem Cell Derived Exosomes Alleviates Hirschsprung-Associated Enterocolitis by Inhibiting AKT Phosphorylation in Macrophages Through miR-223

Stem Cells International
Conclusion: Macrophages accumulate in colonic tissues during HAEC and inflammatory macrophages drive enterocyte death. MSCs derived exosomes reduce enterocyte death by suppressing AKT phosphorylation and IL-1β secretion via miR-223, and subsequently ...
Haosen Ji, Zheming Xu, Leiting Shen, Sisi Yang, Jingyi Jin, Chengjie Lyu, Yichao Ren, Yi Xiao, Yuebai Zhang, Shu Fang, Xiaoxia Zhao, Xiang Yan, Dengming Lai, Jinfa Tou   +13 more
doaj   +1 more source

A retrospective audit of neonatal BCG vaccination in Grampian, Scotland

Human Vaccines & Immunotherapeutics, 2023
Bacillus Calmette–Guerin (BCG) vaccine confers protection against tuberculosis (TB) and works most effectively when given to infants. Scotland runs a risk-based program in which BCG vaccine is offered to infants whose parent or grandparent was born in a ...
Saba Savul, Susan Duthie
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

National performance indicators to support neonatal hearing screening in Australia [PDF]

, 2013
This paper presents a set of performance indicators for monitoring neonatal hearing screening activity in Australia at a national level, to help measure how well neonatal hearing screening is achieving its aims.SummaryEach year in Australia ...

core