Results 161 to 170 of about 34,890 (296)

MECP2 Gene-Related Severe Neonatal Encephalopathy: A Rare Case in a Female Neonate. [PDF]

Cureus
Devi R, Gupta D, Rc PK, Singh P, Priyadarshi M, Chaurasia S, Basu S.   +6 more
europepmc   +1 more source

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Sleep disruptions are common in hospitalised children. This study described sleep in critically ill and non‐critically ill hospitalised children, including young infants and patients with central nervous system injuries. Methods This observational cohort study included two groups: critically ill children admitted to a paediatric intensive ...
Eris van Twist, Arnout B. G. Cramer, Sascha C. A. T. Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F. M. Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C. G. Straver, Rogier C. J. de Jonge   +9 more
wiley   +1 more source

Adult Perspectives on the Long-term Impact of Neonatal Encephalopathy Due to Hypoxia-Ischemia. [PDF]

Neuropediatrics
Parmentier CEJ, van den Broek BTP, Welles R, Bel EJG, Busstra WG, Lequin MH, van der Aa NE, de Vries LS.   +7 more
europepmc   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

An epigenetic perspective on neonatal encephalopathy with suspected hypoxic ischaemic encephalopathy. [PDF]

Clin Epigenetics
Mistry P, Mellet J, Durandt C, Smuts I, Pepper MS.   +4 more
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Development of a prediction model for mortality in infants undergoing therapeutic hypothermia for neonatal encephalopathy. [PDF]

J Perinatol
Mitchell JM, Rodrigues CL, Dunworth M, Mc Ginley J, O'Byrne L, Hall R, Corcoran P, Campillo ISL, Mc Kenna P, Higgins JR, McKernan J, Khashan AS, Maher GM, Murphy J, Walsh BH, Greene RA, McCarthy FP.   +16 more
europepmc   +1 more source

Expanding Spectrum of FIG4‐Related Neurological Disorders of Lysosomal Homeostasis: Case Report and Overview of the Potential Genotype–Phenotype Correlations

Clinical Genetics, EarlyView.
FIG4 is essential for lysosomal homeostasis. FIG4‐related disorders present as a continuous spectrum from the juvenile lethality in Yunis‐Varon syndrome to an increased risk of amyotrophic lateral sclerosis (ALS) in adult life. FIG4‐related disorders comprise a novel group of disorders of lysosomal homeostasis and can be classified into severe ...
Pankaj Prasun, Matthew Rasberry
wiley   +1 more source

Expert Consensus Approach to Developing Inpatient Common Data Elements for Neonatal Encephalopathy Research. [PDF]

Neurology
Peeples ES, Mietzsch U, Molloy EJ, Pilon B, Guez-Barber D, Soul J, Mohammad K, deVeber G, Chau V, Bonifacio SL, Craig AK, Afifi J, Sabir H, Groenendaal F, Shany E, Dizon MLV, Iwata O, Okulu E, Jermendy A, Boo NY, El-Dib M, Wintermark P, Newborn Brain Society Guidelines and Publications Committee.   +22 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source