Results 91 to 100 of about 152,103 (313)
Nutritional and metabolic programming during the first thousand days of life
La Pediatria Medica e Chirurgica, 2017 The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development,
Massimo Agosti +3 more
doaj +1 more source
Advanced Science, EarlyView.This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song +10 more
wiley +1 more source
Determinants of Extended Neonatal Intensive Care Unit Stay [PDF]
Iranian Journal of NeonatologyBackground: Prolonged hospitalization in the Neonatal Intensive Care Unit (NICU) escalates healthcare costs and potentially exposes neonates to further complications. This study aimed to identify the significant predictors influencing the length of stay (
Ridha Rahmah +4 more
doaj +1 more source
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source
From the “old NEC” to the “new NECs”
Journal of Pediatric and Neonatal Individualized Medicine, 2014 Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the neonatal intestine that strikes in 1 of 1,000 live births. Its etiology is unknown.
Melania Puddu +6 more
doaj +1 more source
Work-related burden on physicians and nurses working in neonatal intensive care units: a survey [PDF]
, 2015 Aim: This study aimed at exploring the type, degree, and duration of work-related burden on neonatal physicians and nurses working in tertiary level neonatal intensive care units, its impact on their private life, and at assessing which coping strategies
Klein, Sabine; https://orcid.org/ +4 more
core +1 more source
Advanced Science, EarlyView.An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng +9 more
wiley +1 more source
Collaboration, participation and non-participation: decisions about involvement in randomised controlled trials for clinicians and parents in two neonatal trials [PDF]
Background: The ethical basis of randomised controlled trials is equipoise, whether at the collective or individual level. Neonatal intensive care trials are therefore conducted in a context of clinical uncertainty as well as stress
Snowdon, Claire
core +1 more source
Advanced Science, EarlyView.Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li +13 more
wiley +1 more source
Evaluation of Biliary Sludge in Neonatal Intensive Care Patients [PDF]
Objective: This study aimed to evaluate the frequency of biliary sludge, the presence of defined risk factors, and the clinical course in infants followed in the neonatal intensive care unit (NICU).
Cemre ÖZENBAŞ, Burçin İŞCAN
core +1 more source