Results 21 to 30 of about 95,410 (219)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Late-preterm birth in a level III hospital: incidence and associated morbidity

Journal of Pediatric and Neonatal Individualized Medicine, 2016
Introduction: Late-preterm infants are physiologically and metabolically immature and have important risk of morbidity and mortality. Aim: To analyze the incidence of late prematurity and its associated morbidity and mortality at a level III hospital ...
Carla Garcez, Nicole Silva, Liliana Pinheiro, Miguel Costa, Carla Sá, Eduarda Abreu, Albina Silva, Almerinda Pereira   +7 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Therapeutic Hypothermia in Asphyxiated Neonates: Experience from Neonatal Intensive Care Unit of University Hospital of Marrakech

International Journal of Pediatrics, 2017
Introduction. Therapeutic hypothermia (TH) is now recommended for the treatment neonates with hypoxic-ischemic encephalopathy (HIE). This treatment protocol is applied in our department since June 2012.
F. M. R. Maoulainine, M. Elbaz, S. Elfaiq, G. Boufrioua, F. Z. Elalouani, M. Barkane, Nadia El Idrissi Slitine   +6 more
doaj   +1 more source

Antimicrobial Resistance Pattern and Empirical Antibiotic Treatments in Neonatal Sepsis: A Retrospective, Single-Center, 12-Year Study

Antibiotics, 2023
Neonatal sepsis is an important cause of morbidity and mortality in neonatal intensive care units (NICUs). Continuous evaluation of antimicrobial resistance (AMR) profiles is advised to implement antimicrobial stewardship (AMS) programs and establish ...
Chiara Minotti, Antonella Di Caprio, Laura Facchini, Luca Bedetti, Francesca Miselli, Cecilia Rossi, Elisa Della Casa Muttini, Licia Lugli, Laura Luppi, Filippo Ferrari, Alberto Berardi   +10 more
doaj   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Update on COVID-19 in the pediatric population at University Hospital of Oran. A retrospective study [PDF]

Batna Journal of Medical Sciences
Introduction. The spread of the novel coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic in Algeria as early as February. Children and adolescents under the age of 18 were much more rarely affected than adults and account ...
Djamila-Djahida BATOUCHE, Zakaria Zoheir ADDOU, Kamel ELHALIMI, Amel BOUGUERRA, Fouzia BOUNOUA, Djilali BATOUCHE, Sid Ahmed BAKRI, Houcine SADDOK, Fatima Zohra LATRECHE, Sara-Halima MOHAMMEDI   +9 more
doaj   +1 more source

Comparison of three clinical scoring tools for bronchiolitis to predict the need for respiratory support and length of stay in neonates and infants up to three months of age

Frontiers in Pediatrics, 2023
BackgroundBronchiolitis severity can be assessed using different clinical scores. Some of the most used are the Wang Bronchiolitis Severity Score (WBSS), the Kristjansson Respiratory Score (KRS), and the Global Respiratory Severity Score (GRSS ...
Domenico Umberto De Rose, Chiara Maddaloni, Ludovica Martini, Annabella Braguglia, Andrea Dotta, Cinzia Auriti   +5 more
doaj   +1 more source