Results 41 to 50 of about 399,368 (309)

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Molecular detection of Coxiella Burnetii in ovine abortions: evidence from a three-year surveillance in an endemic region

Veterinary and Animal Science
Coxiella burnetii, an obligate intracellular coccobacillus, is a major cause of abortion in livestock and a re-emerging zoonotic pathogen responsible for Q fever in humans. Iran, particularly Khorasan-e-Razavi Province, is considered endemic for Q fever.
Pegah Sagha Nosrati, Khadijeh Hashemi, Narges Khaleghnia, Mehrdad Mohri, Pezhman Mirshokraei   +4 more
doaj   +1 more source

Burden, timing and causes of maternal and neonatal deaths and stillbirths in sub-Saharan Africa and South Asia: Protocol for a prospective cohort study [PDF]

, 2016
OBJECTIVES: The AMANHI mortality study aims to use harmonized methods, across eleven sites in eight countries in South Asia and sub–Saharan Africa, to estimate the burden, timing and causes of maternal, fetal and neonatal deaths. It will generate data to
Abdul Quaiyum, Mohammad, AMANHI study group, Kalonji, Michel, Ngaima, Seige, Nguwo, Andre, Otomba, John, Tshefu, Antoinette   +6 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Can qPCR on pooled sheep milk detect brucellosis as part of herd brucellosis control and eradication programs?

BMC Veterinary Research
Background Brucellosis is a zoonotic disease occurring worldwide. Brucella melitensis is the main cause of malta fever in humans and a major cause of abortion in sheep.
Mohammad Javad Aminzadeh, Khadijeh Hashemi, Hamideh Kalateh Rahmani, Narges Khaleghnia, Mohammad Azizzadeh, Pezhman Mirshokraei   +5 more
doaj   +1 more source

Determinants of early neonatal mortality (hospital based retrospective cohort study in Somali region of Ethiopia)

Scientific Reports, 2023
Early neonatal mortality occurs when a newborn dies within the first seven days of life. Despite interventions, neonatal mortality remains public health problem over time in Ethiopia (33 per 1000 live births).
Ahmed Tahir Ahmed, Abdifatah Elmi Farah, Hussein Nooh Ali, Muse Obsiye Ibrahim   +3 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Predictors and disparities in neonatal and under 5 mortality in rural Pakistan: cross sectional analysisResearch in context

The Lancet Regional Health - Southeast Asia, 2023
Summary: Background: Adopted in 2015, the sustainable development goals (SDGs) have set specific targets (SDG 3.2) for countries to reduce their neonatal mortality rate (NMR) to below 12 deaths per 1000 live births and under 5 mortality rate (U5MR) to ...
Zahid Memon, Daniel Fridman, Sajid Soofi, Wardah Ahmed, Shah Muhammad, Arjumand Rizvi, Imran Ahmed, James Wright, Simon Cousens, Zulfiqar A. Bhutta   +9 more
doaj   +1 more source

Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. [PDF]

, 2018
OBJECTIVE: To assess the morbidity associated with continuing the second-stage duration of labor, weighing the probability of spontaneous vaginal birth without morbidity compared with birth with serious maternal or neonatal complications.
Allen, Cheng, Cohen, Hamilton, Hamilton, Hellman, Laughon, Menticoglou, Moon, Myles, Rouse, Saunders, Scrucca, Spong, Zhang   +14 more
core   +2 more sources