Results 51 to 60 of about 1,782,260 (305)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Neonatal mortality in developing countries: an analysis of trends and determinants

, 2009
There is limited understanding of how both trends and determinants of neonatal mortality vary from post-neonatal mortality, and more specifically how health care variables are associated with deaths in the first month of life.
Neal, Sarah Elizabeth
core   +1 more source

Can qPCR on pooled sheep milk detect brucellosis as part of herd brucellosis control and eradication programs?

BMC Veterinary Research
Background Brucellosis is a zoonotic disease occurring worldwide. Brucella melitensis is the main cause of malta fever in humans and a major cause of abortion in sheep.
Mohammad Javad Aminzadeh, Khadijeh Hashemi, Hamideh Kalateh Rahmani, Narges Khaleghnia, Mohammad Azizzadeh, Pezhman Mirshokraei   +5 more
doaj   +1 more source

Perinatal mortality in rural Burkina Faso: a prospective community-based cohort study. [PDF]

, 2010
BACKGROUND: There is a scarcity of reliable data on perinatal mortality (PNM) in Sub-Saharan Africa. The PROMISE-EBF trial, during which we promoted exclusive breastfeeding, gave us the opportunity to describe the epidemiology of PNM in Banfora Health ...
Emmanuel Zabsonré, Cousens, Simon, Meda, Nicolas, Halvor Sommerfelt, Tylleskär, Thorkild, Diallo, Abdoulaye Hama, PROMISE-EBF Study Group, Meda Nicolas, Zabsonré, Emmanuel, null null, Abdoulaye Hama Diallo, Cousens Simon, Tylleskär Thorkild, Simon Cousens, Diallo Abdoulaye, Sommerfelt, Halvor, Thorkild Tylleskär, Zabsonré Emmanuel, Sommerfelt Halvor, Nicolas Meda   +19 more
core   +2 more sources

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Predictors and disparities in neonatal and under 5 mortality in rural Pakistan: cross sectional analysisResearch in context

The Lancet Regional Health - Southeast Asia, 2023
Summary: Background: Adopted in 2015, the sustainable development goals (SDGs) have set specific targets (SDG 3.2) for countries to reduce their neonatal mortality rate (NMR) to below 12 deaths per 1000 live births and under 5 mortality rate (U5MR) to ...
Zahid Memon, Daniel Fridman, Sajid Soofi, Wardah Ahmed, Shah Muhammad, Arjumand Rizvi, Imran Ahmed, James Wright, Simon Cousens, Zulfiqar A. Bhutta   +9 more
doaj   +1 more source

Predictors of Positive Blood Culture and Deaths Among Neonates with Suspected Neonatal Sepsis in a Tertiary Hospital, Mwanza-Tanzania. [PDF]

, 2010
Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis and empirical treatment in a given setting is crucial as pathogens of bacterial sepsis and antibiotic sensitivity pattern can considerably vary ...
Kamugisha, Erasmus, Jeremiah, Seni, Mwizamholya Damas L, Stephen E Mshana, Kamugisha Erasmus, Erasmus Kamugisha, Damas L Mwizamholya, Mshana Stephen E, Mwizamholya, Damas L, Kayange, Neema, Neema Kayange, Jeremiah Seni, Kayange Neema, Mshana, Stephen E, Seni Jeremiah   +14 more
core   +2 more sources

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Assessing some of the associations with perinatal mortality at Kamuzu central hospital in Lilongwe, Malawi [PDF]

, 2012
Includes bibliographical references.The study objectives were to: determine the prevalence of perinatal mortality (PNM) and causes of early neonatal deaths (ENNDs), describe socio-demographic factors of mothers with PNM and assess some of the ...
Mwenyekonde, Elled
core   +1 more source