Results 161 to 170 of about 39,708 (253)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children. [PDF]

Pediatr Neurol
Mattes AM, Shellhaas RA, Glass HC, Sturza J, Rau S, Lemmon M, Rogers EE, Numis A, Soul JS, Berl M, Wusthoff CJ, Chu CJ, Massey SL, Thomas C, Franck LS, McCulloch CE, Benedetti GM, Means J, Means K, Anwar T, Gidley Larson JC.   +20 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Sleep Disorders Five Years After Acute Provoked Neonatal Seizures. [PDF]

J Pediatr
Shellhaas RA, Franck LS, Pilon B, Wusthoff CJ, Massey SL, Chu CJ, Soul JS, Lemmon ME, Numis AL, Sturza JS, Thomas C, Benedetti GM, Rau SMD, Anwar T, Berl MM, McCulloch CE, Glass HC.   +16 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Postneonatal epilepsy after acute provoked neonatal seizures: Incidence, predictors, and clinical burden in a multicenter cohort followed through early childhood. [PDF]

Epilepsia
Numis AL, Glass HC, Soul JS, Wusthoff CJ, Massey SL, Benedetti GM, Chu CJ, Thomas C, Anwar T, Lemmon ME, Franck LS, Berl MM, Pilon B, Rau SMD, Li Y, Sturza J, McCulloch CE, Shellhaas RA.   +17 more
europepmc   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Neonatal Seizures: New Evidence, Classification, and Guidelines. [PDF]

Epilepsy Curr
Ziobro J, Pilon B, Wusthoff CJ, Benedetti GM, Massey SL, Yozawitz E, Numis AL, Pressler R, Shellhaas RA.   +8 more
europepmc   +1 more source

Therapy of neonatal seizures

Cleveland Clinic Journal of Medicine, 1989
openaire   +2 more sources

Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong, Jungryul Kim, Woojin Jung, Jiyeon Jeon, Hyeongjun Jo, Kyoung‐Bin Ryu, Ja‐Young Hong, Kwan Soo Kim, Seongjun Yang, Hee Young Ju, Hwi‐yeol Yun, Jung‐woo Chae, Keon Hee Yoo, Soyoung Lee   +13 more
wiley   +1 more source