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Model‐Informed Dose Optimization of Anakinra in Preterm Neonates Implications for Safe and Effective Dosing

Clinical Pharmacology &Therapeutics, EarlyView.
Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li, David K. Metz, Elys Green, Gergely Toldi, Robert Galinsky, Megan Clark, Rebecka Atkinson, Ina Rudloff, Josephine C. Owen, Sara K. DiSimone, Samuel C. Forster, Steven X. Cho, Atif Majid, Graeme R. Polglase, Marcel Favilla, Pramod Pharande, Atul Malhotra, Calum T. Roberts, Scott H. Stansfield, Arvind Sehgal, Kenneth Tan, Alistair J. Gunn, Philip J. Berger, Alex Veldman, Rod W. Hunt, Claudia A. Nold‐Petry, Marcel F. Nold, Carl M. J. Kirkpatrick   +27 more
wiley   +1 more source

Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures. [PDF]

IBRO Neurosci Rep
Ghotbeddin Z, Badripour N, Amini-Khoei H, Basir Z, Balali-Dehkordi S.   +4 more
europepmc   +1 more source

Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States. [PDF]

Pediatr Neurol
Peng GS, Halsey K, Wusthoff CJ, Chu CJ, Massey SL, Lemmon ME, Thomas C, Numis AL, Benedetti GM, Sturza J, Rogers EE, Franck LS, McCulloch CE, Soul JS, Shellhaas RA, Bonifacio SL, Glass HC.   +16 more
europepmc   +1 more source

Timing of interventions to control neuronal chloride elevation in a model of neonatal seizures after hippocampal injury. [PDF]

Epilepsia
Dzhala VI, Mail M, Staley KJ.
europepmc   +1 more source

Finding My Path: Listening, Learning, and Leading in Rare Disease: The 2025 Hower Award

Annals of the Child Neurology Society, EarlyView.
Andrea Gropman
wiley   +1 more source

Comparative Outcomes of Levetiracetam and Phenobarbital Usage in the Treatment of Neonatal Seizures: A Retrospective Analysis. [PDF]

Healthcare (Basel)
Toptan HH, Karadag NN, Topcuoglu S, Ozalkaya E, Dincer E, Cakir H, Gunes AO, Karatekin G.   +7 more
europepmc   +1 more source

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Neonatal Seizures

New England Journal of Medicine, 2023
(N Engl J Med. 2023;388:1692–1700. doi: 10.1056/NEJMra2300188) Seizures that occur within 4 weeks of the birth of a term infant or 44 weeks of corrected gestational age for preterm infants are defined as neonatal seizures, and the incidence is estimated at 2.29 per 1000 live births.
Elissa Yozawitz
exaly   +3 more sources

Neonatal Seizures

New England Journal of Medicine, 1973
exaly   +4 more sources

Neonatal seizures

Current Treatment Options in Neurology, 2001
Neonatal seizures are frequently manifested by subtle movements that are referable to brain stem structure, ie, nystagmus, conjugate eye movements, posturing, sucking movements, and so forth. Electroencephalogram (EEG) confirmation of abnormal movements is essential in diagnosing seizures in the neonate.
Michael J., Painter, John, Alvin
openaire   +2 more sources