Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic. [PDF]
Lin F +6 more
europepmc +1 more source
A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley +1 more source
Molecular Characterization and Clinical Outcomes of <i>Klebsiella pneumoniae</i> in Neonatal Sepsis: A Three-Year Molecular Epidemiological Study. [PDF]
Villavicencio-Carrisoza O +19 more
europepmc +1 more source
ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
Epidemiology, microbiological profile, and antimicrobial resistance patterns of culture-proven neonatal sepsis in a tertiary NICU. [PDF]
Bayar V +5 more
europepmc +1 more source
Association of Elevated C‐Reactive Protein in Term Newborns With Neonatal Factors and Gut Microbiota
ABSTRACT Aim Plasma C‐reactive protein (CRP) is widely used to assess neonatal infection, although mild, unexplained elevations are common in healthy newborns. We examined relationships between non‐infectious CRP levels and neonatal factors, and early gut microbiota composition in term infants.
Susanna Gardemeister +6 more
wiley +1 more source
Neonatal Sepsis: Pathogens, Clinical Challenges, and Emerging Solutions. [PDF]
Green M, Chawla J, Blavo C.
europepmc +1 more source
Frequency, Burden and Pathogens of Acute Respiratory Illness in Very Preterm Infants During Infancy
ABSTRACT Aim To describe the frequency, burden, and pathogen profile of acute respiratory illnesses (ARIs) in very preterm infants during the first year after neonatal intensive care unit (NICU) discharge. Methods Very preterm infants were followed prospectively (August 2015–January 2017) with monthly assessments of symptoms, medication use, and ...
Patricia De Gouveia Belinelo +9 more
wiley +1 more source
N-Acetylcysteine protects the developing brain in neonatal sepsis-like inflammation via a redox-neurovascular pathway. [PDF]
Cheng P +13 more
europepmc +1 more source
Trained Immunity in Childhood Vaccination
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai +2 more
wiley +1 more source

