Results 61 to 70 of about 2,723 (212)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Ressecção de adenocarcinoma retal por osteotomia púbica e isquiática em cão: Relato de caso

Pubvet, 2022
As neoplasias que acometem intestinos de cães são de baixa ocorrência e representam menos de 10% de todas as neoplasias malignas na espécie. Os sinais observados podem incluir tenesmo, diarreia, disquesia, hematoquezia, prolapso anal, anorexia e perda de
Giovanna Lapkoski Bonatto, Natalia Noreika Kano, Carolina Konkel Barbosa, Wiliam da Silva Prieto, Leticia Fernanda Laube, Robson Junior Piontkovsky, Renato Silva de Sousa, Bruna Fernanda Firmo, Roberta Carareto   +8 more
doaj   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Neoplasia de colon

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2014
El cáncer de colon es un tumor que se desarrolla por degeneración maligna de las células del intestino grueso, desde la válvula ileocecal hasta la flexura recto sigmoidea. Se presenta el caso de un paciente masculino, de 75 años, con astenia anorexia y pérdida de peso; al examen físico: mucosas hipocoloreadas, abdomen blando no doloroso a la palpación ...
openaire   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Localización nuclear del dominio extracelular de MUC1 en neoplasias de mama, colon, cabeza y cuello

, 2013
Facultad de Ciencias ...
Rabassa, Martín Enrique, Isla Larrain, Marina Teresita, Lacunza, Ezequiel, Cermignani, L., Alberdi, Cecilio G., Demichelis, Sandra O., Abba, Martín Carlos, Segal-Eiras, Amada, Croce, María Virginia   +8 more
openaire   +2 more sources

Tapeworm testing: Coprological and antibody‐based approaches across colic types in a German equine hospital population

Equine Veterinary Education, EarlyView.
Summary Background The association between tapeworm infection and equine colic is established, but gaps remain regarding specific colic types. Objectives To assess the relationship between tapeworm test results and equine colic types: The study aimed to determine if ileocaecal disorders (IC) are more frequently associated with Anoplocephala spp ...
K. L. Adamasky, K. Drozdzewska, P. Schmitz, N. Peczak, K. L. Lightbody, J. B. Matthews, M. K. Nielsen, R. Merle, G. von Samson‐Himmelstjerna, H. Gehlen   +9 more
wiley   +1 more source

Infección necrosante de tejidos blandos y neoplasia gastrointestinal

Infectio
Las infecciones necrosantes de tejidos blandos presentan altas tasas de mortalidad. Estas se han relacionado con diferentes causas, incluidas las enfermedades neoplásicas.
Lina María Villa Sánchez, Sonia Isabel Cuervo Maldonado, Julio César Gómez Rincón, Mariam Carolina Rolón Cadena   +3 more
doaj  

PAPEL DE LAS IMÁGENES EN EL ESTUDIO DE LOS SÍNDROMES NEOPLÁSICOS HEREDITARIOS

Revista Médica Clínica Las Condes, 2017
Este artículo analiza el rol de las imágenes en diferentes síndromes neoplásicos hereditarios, incluyendo mama, colon y neoplasias endocrinas múltiples. Las mujeres con mutaciones genéticas asociadas a mayor susceptibilidad de desarrollar cáncer de mama ...
Dra. Paulina Neira, Dra. Carolina Behnke, Dr. Andrés O’Brien, Dr. Rodrigo Jaimovich   +3 more
doaj   +1 more source

Tuberculosis intestinal como simuladora de una neoplasia de colon

Revista de Gastroenterología de México, 2023
A. Suárez-Noya, O. González-Bernardo, J.R. Riera-Velasco, A. Suárez   +3 more
openaire   +2 more sources