Results 81 to 90 of about 61,302,721 (213)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
Determinación de subtipos tumorales basales en neoplasias mamarias caninas
, 2017 En la mujer, la evaluación de las neoplasias mamarias contempla en la actualidad, la determinación por inmunomarcación de diferentes proteínas que brindan una base para un algoritmo diagnóstico de subtipos tumorales: Basales, luminales tipo A, luminales
Barrios, Mauricio Martín
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Tumores estromales gastrointestinales: Evolución conceptual.
Revista de la Facultad de Ciencias Médicas de Córdoba, 2004 Los tumores estrornales gastrointestinales (GastroIntestinal Stromal Tuniors - GISTs—) constituyen la categoría más amplia de neoplasias no epiteliales primarias del tracto gastrointestinal y representan aproximadamente el 1-2% de todas las neoplasias ...
Ismael B Fonseca +5 more
doaj +1 more source
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid [PDF]
, 2006 Background: Red meat consumption is associated with an increased risk of colon cancer. Animal studies show that heme, found in red meat, promotes preneoplastic lesions in the colon, probably due to the oxidative properties of this compound.
G. Gottardi +21 more
core +1 more source
Anales de la Facultad de MedicinaLos tumores neuroendocrinos del colon sigmoides con células grandes son neoplasias infrecuentes. La mayoría de los casos presentan metástasis al momento del diagnóstico, lo que dificulta el manejo. Además, tienen un pronóstico desfavorable debido al bajo
Edgar Fermín Yan-Quiroz +4 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff +3 more
wiley +1 more source
Neoplasias mamarias caninas : determinación de subtipos tumorales basales por medio de ck14
, 2016 Las neoplasias mamarias presentan una elevada incidencia en la población de hembras caninas en nuestro país y las manifestaciones malignas, superan el 90% en la región nordeste argentina. Estas neoplasias se caracterizan por su heterogeneidad histológica,
Barrios, Mauricio Martín
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Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review
Clinical Genetics, EarlyView.There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson +6 more
wiley +1 more source
Absentismo eclesiástico en Canarias
, 1964 Visitado el 24 de febrero de ...
Domínguez Ortiz, Antonio +1 more
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