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Vulvar intraepithelial neoplasia
Best Practice & Research Clinical Obstetrics & Gynaecology, 2014Vulvar intraepithelial neoplasia (VIN) is a high-grade intraepithelial squamous lesion and precursor of invasive squamous cell carcinoma (SCC). The 2004 International Society for the Study of Vulvovaginal Disease (ISSVD) classification distinguished two types of VIN: usual type (human papillomavirus (HPV)-related) and differentiated type (not HPV ...
Preti M +3 more
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The pathology of vulvar neoplasia
Current Opinion in Obstetrics and Gynecology, 1996Current literature on the pathology of vulvar disease continues to focus on vulvar intraepithelial neoplasia, the role of human papillomavirus in vulvar neoplasia, and Paget's disease of the vulva. Of particular concern is an increasing incidence of vulvar intraepithelial neoplasia noted over the past several decades, specifically among younger women ...
R A, Lininger, F A, Tavassoli
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American Journal of Obstetrics and Gynecology, 1979
Vulvar intraepithelial neoplasms may be occurring more frequently among younger age groups. Six patients with carcinoma in situ or severe vulvar dysplasia are reported, as well as one patient with microinvasive carcinoma, all under the age of 30 years. The vulvar lesions were noted to be mostly multicentric.
G D, Hilliard, F M, Massey, R V, O'Toole
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Vulvar intraepithelial neoplasms may be occurring more frequently among younger age groups. Six patients with carcinoma in situ or severe vulvar dysplasia are reported, as well as one patient with microinvasive carcinoma, all under the age of 30 years. The vulvar lesions were noted to be mostly multicentric.
G D, Hilliard, F M, Massey, R V, O'Toole
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Angiogenesis in Vulvar Intraepithelial Neoplasia
Gynecologic Oncology, 1997Vulvar intraepithelial neoplasia (VIN) has been reported to be a precursor of invasive vulvar cancer. Switching to the angiogenic phenotype is considered a key step in tumor growth. Microvessel density (MVD) and vascular endothelial growth factor (VEGF), a highly angiogenic peptide, are important parameters of tumor angiogenesis. Forty-three histologic
Banchertodesca, D +7 more
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Erosive Vulvar Lichen Planus and Risk of Vulvar Neoplasia
Journal of Lower Genital Tract Disease, 2020Objective The aim of the study was to assess the risk of vulvar cancer and precursors in a cohort of women with vulvar lichen planus (LP) and the clinical and therapeutic features of these patients. Materials and Methods A retrospective cohort study, including all the women with the
Joana, Lyra +6 more
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Pathobiology of vulvar squamous neoplasia
Current Opinion in Obstetrics and Gynecology, 1997Vulvar squamous carcinoma is an uncommon neoplasm that afflicts a spectrum of women and has been associated with granulomatous vulvar diseases, papillomaviruses, and chronic inflammatory disorders of the vulva. Histopathological, molecular, and epidemiological studies have revealed two subsets of vulvar squamous neoplasia, which are distinguished by ...
C P, Crum +3 more
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Intraepithelial neoplasia in the vulvar region
Gynecologic Oncology, 1985From 1978 to 1982, 49 patients with intraepithelial neoplasia in the vulvar region were included in a prospective investigation. The main purpose was to evaluate the effect of treatment by local excision with a free margin of 2 mm and to estimate the importance of colposcopy.
B, Andreasson, J E, Bock
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Vulvar intraepithelial neoplasia and carcinoma
Seminars in Cutaneous Medicine and Surgery, 1998This report describes the classification, clinical profile, etiology, and management of high-grade squamous vulvar intraepithelial-neoplasia (VIN). Recent studies have better defined the progressive potential of high-grade VIN and the relationship of such lesions to squamous vulvar carcinoma.
M J, Campion, N F, Hacker
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Vulvar Intraepithelial Neoplasia
Journal of Lower Genital Tract Disease, 2012The study aimed to evaluate effectiveness and recurrence rate of vulvar intraepithelial neoplasia (VIN) treatment according to treatment modalities as follows: imiquimod (Aldara), laser ablation, laser excision, wide local excision, and skinning vulvectomy.
Filipa, Ribeiro +3 more
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Vulvar Dystrophies and Intraepithelial Neoplasias
Obstetrics and Gynecology Clinics of North America, 1987The warmth and moisture present in all intertriginous locations distorts the lesional morphology of many vulvar diseases. Specifically, wetness leads to the development of a nondistinctive, white hyperhydration of any scale that is present, and this, in turn, masks the characteristic features of the underlying pathology. These same factors increase the
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