Results 61 to 70 of about 199,596 (304)

Co-occurrence of ovarian Yolk Sac Tumor and pancreatic solid pseudopapillary neoplasm in a pediatric patient: A case report [PDF]

Background: Multiple malignant neoplasms in pediatric patients are rare, posing diagnostic and therapeutic challenges. This case report details a 12-year-old girl with a Yolk Sac Tumor (YST) found to have a Solid Pseudopapillary Neoplasm (SPN) of the ...
S. Sorrentino, L. Piro, V. Capra, F. Palo, A. Roggero, E. Arkhangelskaya, M. Conte, D. Paoloni, V.G. Vellone, S. Avanzini, P. De Marco, J. Ferro   +11 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms

Transplantation and Cellular Therapy, 2023
Next-generation sequencing (NGS) is used to monitor genetically measurable residual disease (gMRD) following allogeneic stem cell transplantation (aSCT). It is unknown whether an upper limit of chimerism exists such that gMRD NGS testing can be safely forgone.
Christian J. Puzo, Christopher A. Tormey, Henry M. Rinder, Alexa J. Siddon   +3 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Clinical Significance of Extranodal Extension in Non-small Cell Lung Cancer: 
Current Status and Future Prospects

Chinese Journal of Lung Cancer
Global cancer statistics in 2022 ranked lung cancer as the leading cause of cancer incidence and mortality worldwide, with lymph node metastasis serving as a pivotal determinant of prognosis and treatment strategy.
Han LIANG, Yajie MENG, Qi WANG, Caifan LI, Hao YANG, Xudong XIANG   +5 more
doaj   +1 more source

Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives

Cancers
Myelodysplastic Neoplasms (MDS) have been traditionally studied through the assessment of blood counts, cytogenetics, and morphology. In recent years, the introduction of molecular assays has improved our ability to diagnose MDS. The role of Measurable (minimal) Residual Disease (MRD) in MDS is evolving, and molecular and flow cytometry techniques have
Linsheng Zhang, George Deeb, Kristin K. Deeb, Colin Vale, Deniz Peker Barclift, Nikolaos Papadantonakis   +5 more
openaire   +2 more sources

Study of minimal residual disease as a prognostic factor in acute lymphoblastic leukemia in pediatric patients. [PDF]

, 2023
tablas.La leucemia linfoblástica aguda es la neoplasia pediátrica más frecuente representando entre el 75% a 80% de los casos de leucemias agudas en infantes.
Pulgar Quintuña, Josselyn Alexandra
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

CHONDROMYXOID FIBROMA OF BONE [PDF]

, 1960
1. A case of chondromyxoid fibroma of the tibia is reported. 2. Initial removal by curettage was followed by regrowth of residual foci; these were removed by a second curettage three years later.
W. W. Park, J. Hutchison
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source