Results 141 to 150 of about 1,399,570 (292)

Open synovectomy for treatment of tenosynovial giant cell tumors of the knee in children. [PDF]

J Surg Case Rep
Georgiev H, Gecheva N, Gerchev A, Tserovski S, Nenov DN, Patrikov K.   +5 more
europepmc   +1 more source

Drug Development Pipeline for Myeloproliferative Neoplasms: Potential Future Impact on Guidelines and Management [PDF]

, 2016
Prithviraj Bose, Srđan Verstovšek
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Early GLP-1 Agonist Use and Cancer Risk in Type 2 Diabetes: A Real-World Data Cohort Study. [PDF]

Oncol Res
Chuang CH, Tsai PK, Kao SW, Wang YH, Yeh CB.   +4 more
europepmc   +1 more source

Heterogeneity in B‐Cell Neoplasms Associated with Rearrangement of the LAZ3 Gene on Chromosome Band 3q27 [PDF]

, 1994
Hitoshi Ohno, Jean‐Pierre Kerckaert, Christian Bastard, Shirou Fukuhara   +3 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Association between antihypertensive drugs and cancer risk: evidence from a population-based study in the Abruzzo region, Southern Italy. [PDF]

BMC Cancer
Marotta A, Di Nicola M, Vicenti C, Borrelli P, Odio C, Giuliani P.   +5 more
europepmc   +1 more source

Personalized Timing for Allogeneic Stem-Cell Transplantation in Hematologic Neoplasms: A Target Trial Emulation Approach Using Multistate Modeling and Microsimulation [PDF]

Caterina Gregorio, Marta Spreafico, Saverio D’Amico, Elisabetta Sauta, Gianluca Asti, Luca Lanino, Cristina Astrid Tentori, Uwe Platzbecker, Torsten Haferlach, María Díez‐Campelo, Pierre Fenaux, Rami S. Komrokji, Matteo Giovanni Della Porta, Francesca Ieva   +13 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Ganglioglioma in the spinal cord of a steer. [PDF]

J Vet Diagn Invest
Matto C, Rivero R, Woolard K, Uzal FA.
europepmc   +1 more source