Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Lobe-Specific Risk of Malignancy in Parotid Gland Lesions: A Milan System-Based Analysis. [PDF]
Laryngoscope Investig OtolaryngolŞerifler S +6 more
europepmc +1 more source
Results of regional chemotherapy of neoplasms of the upper body by temporary mid-torso vascular occlusion [PDF]
, 1964 Paul Clapp +3 more
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Disentangling the genetic relationship between malignant skin neoplasms and sepsis: Evidence from bidirectional Mendelian randomization. [PDF]
Medicine (Baltimore)Liu Q, Jia W, Xia D, Yang L, Gu D.
europepmc +1 more source
Demographics and additional haematologic cancers of patients with histiocytic/dendritic cell neoplasms [PDF]
Paul G. Kemps +11 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Non-Invasive Follicular Cell-Derived Thyroid Neoplasm Composed Entirely of Spindle Cells Harboring NRAS p.Q61R Mutation and Variable Atypia. [PDF]
Endocr PatholOdate T +4 more
europepmc +1 more source
Tu1423 DIGITAL PANCREATOSCOPY IN THE EVALUATION OF MAIN DUCT INTRADUCTAL PAPILLARY MUCINOUS NEOPLASM: A MULTI-CENTER STUDY [PDF]
, 2018 Arvind J. Trindade +9 more
openalex +1 more source