Results 11 to 20 of about 715,082 (295)

Radon and Neoplasms

Toxics, 2023
Radon is a carcinogenic factor, but the effects of the potential carcinogenicity of radon progeny on the human body during the prenatal period have not yet been explored. Based on data regarding the half-lives of radon-222 and radon-220 and their progeny, this paper considers their potential effects on the human body in the prenatal period.
openaire   +3 more sources

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.

Cancer Discovery, 2017
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive hematologic malignancy with dismal outcomes for which no standard therapy exists. We found that primary BPDCN cells were dependent on the antiapoptotic protein BCL2 and were uniformly ...
J. Montero, Jason Stephansky, Tianyu Cai, G. Griffin, Lucía Cabal-Hierro, K. Togami, L. Hogdal, I. Galinsky, E. Morgan, J. Aster, M. Davids, N. LeBoeuf, R. Stone, M. Konopleva, N. Pemmaraju, A. Letai, A. Lane   +16 more
semanticscholar   +1 more source

Incidence and risk factors of gastrointestinal neuroendocrine neoplasm metastasis in liver, lung, bone, and brain: A population‐based study

Cancer Medicine, 2019
Neuroendocrine neoplasm is a rare solid tumor. Metastatic pattern of the gastrointestinal neuroendocrine neoplasm (GI‐NEN) has not been fully explored.
Zhibo Zheng, Chuyan Chen, Ling-Juan Jiang, Xingtong Zhou, Xiaoyan Dai, Yimin Song, Yongning Li   +6 more
semanticscholar   +1 more source

Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

Annals of Surgery, 2017
Objective: The aim of this study was to characterize patterns of local progression following resection for pancreatic intraductal papillary mucinous neoplasms (IPMN) using targeted next-generation sequencing (NGS).
A. Pea, Jun Yu, N. Rezaee, C. Luchini, Jin He, Marco dal Molin, J. Griffin, Helen L. Fedor, Shahriar Fesharakizadeh, R. Salvia, M. Weiss, C. Bassi, J. Cameron, Lei Zheng, A. Scarpa, R. Hruban, A. Lennon, M. Goggins, elliot k fishman, L. Wood   +19 more
semanticscholar   +1 more source

Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients

Scientific Reports, 2016
Enumeration of circulating tumor cells (CTCs) has been proven as a prognostic marker for metastatic colorectal cancer (m-CRC) patients. However, the currently available techniques for capturing and enumerating CTCs lack of required sensitivity to be ...
W. Tsai, J. Chen, Hung-Jen Shao, Jen-chia Wu, Jr-Ming Lai, Si-Hong Lu, Tsung-Fu Hung, Yen-Chi Chiu, Jeng-Fu You, P. Hsieh, Chien‐Yuh Yeh, Hsin-Yuan Hung, Sum-Fu Chiang, G. Lin, R. Tang, Ying-Chih Chang   +15 more
semanticscholar   +1 more source

Myeloproliferative neoplasm stem cells.

Blood, 2017
Myeloproliferative neoplasms (MPNs) arise in the hematopoietic stem cell (HSC) compartment as a result of the acquisition of somatic mutations in a single HSC that provides a selective advantage to mutant HSC over normal HSC and promotes myeloid ...
A. Mead, A. Mullally
semanticscholar   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source