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Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Carcinogénesis</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Salud Pública de México</i>, 2011 </span><br><span class="r_content">La división celular es controlada por una serie de sistemas que tienen efectos estimulantes o inhibitorios.El cáncer es de origen monoclonal, y para que una célula normal cambie su fenotipo y se convierta en una célula neoplásica deben ocurrir mutaciones </span><br><span class="r_sub"><i>María Teresa Martín de Civetta<span id="ma_2" style="display:none">, Julio Domingo Civetta</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_2')">+1 more</a></small></i></span><br><small><a href="https://doaj.org/article/932b3a99d15c423db0b8111a5ca24fb7" target="_blank" rel="nofollow" title="doaj.org/article/932b3a99d15c423db0b8111a5ca24fb7">doaj</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70164" target="_blank" rel="nofollow">Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...</span><br><span class="r_sub"><i>Ivana Rondon‐Lorefice<span id="ma_3" style="display:none">, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_3')">+16 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70164?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70164?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_3" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70164" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70164'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70164)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_3')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70166" target="_blank" rel="nofollow">Next‐generation proteomics improves lung cancer risk prediction</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.</span><br><span class="r_sub"><i>Megha Bhardwaj<span id="ma_4" style="display:none">, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_4')">+4 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70166?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70166?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_4" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70166" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70166'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70166)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_4')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70167" target="_blank" rel="nofollow">Potential therapeutic targeting of BKCa channels in glioblastoma treatment</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.</span><br><span class="r_sub"><i>Kamila Maliszewska‐Olejniczak<span id="ma_5" style="display:none">, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+4 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70167?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70167?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70167" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70167'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70167)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1007/s41669-016-0003-2" target="_blank" rel="nofollow">A single-center cost analysis of treating primary and metastatic brain cancers with either brain laser interstitial thermal therapy (LITT) or craniotomy</a> <b><a href="https://core.ac.uk/download/212865766.pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16">, 2016 </span><br><span class="r_sub"><i>Kim, Albert H<span id="ma_6" style="display:none">, Leuthardt, Eric C, Sylvester, Pete, Voigt, Jeff</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+3 more</a></small></i></span><br><small><a href="https://core.ac.uk/works/40436316" target="_blank" rel="nofollow" title="core.ac.uk/works/40436316">core</a> </small>   <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1007%2Fs41669-016-0003-2" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=7723&context=open_access_pubs" target="_blank" rel="nofollow" title="digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=7723&context=open_access_pubs">digitalcommons.wustl.edu</a><br> <a href="javascript:navigator.clipboard.writeText('10.1007/s41669-016-0003-2'); alert('Copied the doi');">copy doi</a> <small>(10.1007/s41669-016-0003-2)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+2 more sources</a></small><br></div><div class="r"><p class="r_title"><a href="https://core.ac.uk/download/pdf/6544416.pdf" target="_blank" rel="nofollow">Revisiting the mortality of France and Italy with the multiple-cause-of-death approach</a> <b><a href="http://www.demographic-research.org/volumes/vol23/28/23-28.pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"></span><br><span class="r_content">In this paper, we use the multiple cause-of-death approach to compare the mortality profiles of France and Italy in 2003. Our analysis leads to a substantial re-evaluation of the role played by certain conditions in the process leading to death ...</span><br><span class="r_sub"><i>Aline Desesquelles<span id="ma_7" style="display:none">, France Meslé, Luisa Frova, Marilena Pappagallo, Michele Antonio Salvatore, Monica Pace, Viviana Egidi</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_7')">+6 more</a></small></i></span><br><small><a href="https://core.ac.uk/works/2651285" target="_blank" rel="nofollow" title="core.ac.uk/works/2651285">core</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70168" target="_blank" rel="nofollow">Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.</span><br><span class="r_sub"><i>Ugne Balaseviciute<span id="ma_8" style="display:none">, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+17 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70168?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70168?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70168" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70168'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70168)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70169" target="_blank" rel="nofollow">Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox </span><br><span class="r_sub"><i>Silvia Eller<span id="ma_9" style="display:none">, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+17 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70169?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70169?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70169" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70169'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70169)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70170" target="_blank" rel="nofollow">Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.</span><br><span class="r_sub"><i>Kristin Løge Aanestad<span id="ma_10" style="display:none">, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+35 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70170?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70170?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70170" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70170'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70170)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-humans/" class="suggestion"onclick="show_loader();"><b>humans</b></a><br/><a href="/q-3._good_health/" class="suggestion"onclick="show_loader();"><b>3. good health</b></a><br/><a href="/q-prognosis/" class="suggestion"onclick="show_loader();"><b>prognosis</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-female/" class="suggestion"onclick="show_loader();"><b>female</b></a><br/><a href="/q-male/" class="suggestion"onclick="show_loader();"><b>male</b></a><br/><a href="/q-brain_neoplasms/" class="suggestion"onclick="show_loader();"><b>brain neoplasms</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-thymus_neoplasms/" class="suggestion"onclick="show_loader();"><b>thymus neoplasms</b></a><br/><a href="/q-skin_neoplasms/" class="suggestion"onclick="show_loader();"><b>skin neoplasms</b></a><br/><a href="/q-neoplasm_staging/" class="suggestion"onclick="show_loader();"><b>neoplasm staging</b></a><br/></div></div></div><div class="pagenav"><a href="/q-neoplasm/p-13/" rel="nofollow"><b>previous</b></a>   <a href="/q-neoplasm/p-12/" rel="nofollow">12</a>  <a href="/q-neoplasm/p-13/" rel="nofollow">13</a>  <b>14</b>  <a href="/q-neoplasm/p-15/" rel="nofollow">15</a>  <a href="/q-neoplasm/p-16/" rel="nofollow">16</a>   <a href="/q-neoplasm/p-15/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>