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Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015

Journal of the American Medical Association (JAMA), 2017
L. Turcotte +13 more
semanticscholar +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source

Carcinogénesis</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Salud Pública de México</i>, 2011 </span><br><span class="r_content">La división celular es controlada por una serie de sistemas que tienen efectos estimulantes o inhibitorios.El cáncer es de origen monoclonal, y para que una célula normal cambie su fenotipo y se convierta en una célula neoplásica deben ocurrir mutaciones </span><br><span class="r_sub"><i>María Teresa Martín de Civetta<span id="ma_3" style="display:none">, Julio Domingo Civetta</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_3')">+1 more</a></small></i></span><br><small><a href="https://doaj.org/article/932b3a99d15c423db0b8111a5ca24fb7" target="_blank" rel="nofollow" title="doaj.org/article/932b3a99d15c423db0b8111a5ca24fb7">doaj</a> </small> <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.4274/jpr.galenos.2024.83669" target="_blank" rel="nofollow">Germ Cell Neoplasms of Sacrococcygeal Region: Clinical Characteristics, Outcomes and Analysis of Recurrence after Treatment; A Comprehensive 20-Year Single Center Study</a> <b><a href="https://jpedres.org/pdf/7a593d95-86ec-4d2b-8dd3-26b0d0b79ea4/articles/jpr.galenos.2024.83669/149-154.pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: diamond" title="open access: diamond" width="16" height="16"></span><br><span class="r_sub"><i>Samir Hasan<span id="ma_4" style="display:none">, Ülgen Çeltik, Nazmiye Buyan, Ahmet Çelik, Mustafa Ergün</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_4')">+4 more</a></small></i></span><br><small><a href="https://openalex.org/W4402861598" target="_blank" rel="nofollow" title="openalex.org/W4402861598">openalex</a> </small> <div id="more_4" style="display:none"><a href="/sci_redir.php?doi=10.4274%2Fjpr.galenos.2024.83669" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.4274/jpr.galenos.2024.83669'); alert('Copied the doi');">copy doi</a> <small>(10.4274/jpr.galenos.2024.83669)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_4')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70129" target="_blank" rel="nofollow">Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...</span><br><span class="r_sub"><i>Marco Strecker<span id="ma_5" style="display:none">, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+16 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70129?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70129?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70129" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70129'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70129)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1158/2159-8290.CD-16-0999" target="_blank" rel="nofollow">Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Cancer Discovery</i>, 2017 </span><br><span class="r_sub"><i>J. Montero<span id="ma_6" style="display:none">, Jason Stephansky, Tianyu Cai, G. Griffin, Lucía Cabal-Hierro, K. Togami, L. Hogdal, I. Galinsky, E. Morgan, J. Aster, M. Davids, N. LeBoeuf, R. Stone, M. Konopleva, N. Pemmaraju, A. Letai, A. Lane</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+16 more</a></small></i></span><br><small><a href="https://www.semanticscholar.org/paper/ad3ad099b35357531cdb0684419085d40f527dff" target="_blank" rel="nofollow" title="semanticscholar.org/paper/ad3ad099b35357531cdb0684419085d40f527dff">semanticscholar</a> </small> <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1158%2F2159-8290.CD-16-0999" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1158/2159-8290.CD-16-0999'); alert('Copied the doi');">copy doi</a> <small>(10.1158/2159-8290.CD-16-0999)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70131" target="_blank" rel="nofollow">Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.</span><br><span class="r_sub"><i>Giovanna Maria Stanfoca Casagrande<span id="ma_7" style="display:none">, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_7')">+11 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70131?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70131?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70131" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70131'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70131)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3402/jchimp.v5.26715" target="_blank" rel="nofollow">Acquired tracheoesophageal fistula status post laryngeal neoplasm resection</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: gold" title="open access: gold" width="16" height="16">, 2015 </span><br><span class="r_sub"><i>Sarah Luber, Richard Alweis</i></span><br><small><a href="https://openalex.org/W1996021946" target="_blank" rel="nofollow" title="openalex.org/W1996021946">openalex</a> </small> <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.3402%2Fjchimp.v5.26715" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3402/jchimp.v5.26715'); alert('Copied the doi');">copy doi</a> <small>(10.3402/jchimp.v5.26715)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1038/s41379-019-0362-1" target="_blank" rel="nofollow">Recurrent KRAS mutations in papillary renal neoplasm with reverse polarity</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Modern Pathology</i>, 2019 </span><br><span class="r_sub"><i>Khaleel I. Al-Obaidy<span id="ma_9" style="display:none">, J. Eble, M. Nassiri, Liang Cheng, Mohammad K. Eldomery, S. Williamson, W. Sakr, N. Gupta, O. Hassan, Muhammad T. Idrees, D. Grignon</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+10 more</a></small></i></span><br><small><a href="https://www.semanticscholar.org/paper/d65dca073efd0e740fbca321bde65d005965c765" target="_blank" rel="nofollow" title="semanticscholar.org/paper/d65dca073efd0e740fbca321bde65d005965c765">semanticscholar</a> </small> <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1038%2Fs41379-019-0362-1" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1038/s41379-019-0362-1'); alert('Copied the doi');">copy doi</a> <small>(10.1038/s41379-019-0362-1)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70135" target="_blank" rel="nofollow">Aggressive prostate cancer is associated with pericyte dysfunction</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).</span><br><span class="r_sub"><i>Anabel Martinez‐Romero<span id="ma_10" style="display:none">, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+11 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70135?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70135?mi=2or9o2m&af=R&AllField=neoplasm&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70135" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70135'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70135)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-humans/" class="suggestion"onclick="show_loader();"><b>humans</b></a><br/><a href="/q-biology/" class="suggestion"onclick="show_loader();"><b>biology</b></a><br/><a href="/q-internal_medicine/" class="suggestion"onclick="show_loader();"><b>internal medicine</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-pathology/" class="suggestion"onclick="show_loader();"><b>pathology</b></a><br/><a href="/q-3._good_health/" class="suggestion"onclick="show_loader();"><b>3. good health</b></a><br/><a href="/q-cancer/" class="suggestion"onclick="show_loader();"><b>cancer</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-oncology/" class="suggestion"onclick="show_loader();"><b>oncology</b></a><br/><a href="/q-radiology/" class="suggestion"onclick="show_loader();"><b>radiology</b></a><br/><a href="/q-bone_marrow/" class="suggestion"onclick="show_loader();"><b>bone marrow</b></a><br/></div></div></div><div class="pagenav"><a href="/q-neoplasm/p-17/" rel="nofollow"><b>previous</b></a> <a href="/q-neoplasm/p-16/" rel="nofollow">16</a> <a href="/q-neoplasm/p-17/" rel="nofollow">17</a> <b>18</b> <a href="/q-neoplasm/p-19/" rel="nofollow">19</a> <a href="/q-neoplasm/p-20/" rel="nofollow">20</a> <a href="/q-neoplasm/p-19/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>