Results 71 to 80 of about 1,351,716 (308)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.

, 2014
CVC: central venous catheterization. Data presented as number (%), mean ± SD, or median (interquartile range), as appropriate.Demographic and clinical characteristics of admissions with myeloid neoplasm and lymphoid neoplasm.
Yubin Xing (520421), Mingmei Du (520424), Hui Liu (33624), Jin Zhao (94790), Yunxi Liu (520427), Meng Li (79487), Jijiang Suo (520420)   +6 more
core   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas [PDF]

, 2015
Solid pseudopapillary neoplasm is a rare pancreatic tumour predominantly affecting young women. We present two cases in young female patients.  Both tumours were surgically removed as abdominal masses, one from the pancreatic tail and the other posterior
Waithaka, M, Gakinya, S, Mutuiri, A
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition.

, 2014
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare disease of controversial origin recently recognized as a neoplasm deriving from plasmacytoid dendritic cells (pDCs).
Pileri A. Jr, Gazzola A, Rossi M, Cerroni L, FACCHETTI, Fabio, Arpinati M, Santucci M, Fuligni F, for the AIRC 5xMille consortium ‘Genetics driven targeted management of lymphoid malignancies’, the Italian Registry on Blastic Plasmacytoid Dendritic Cell Neoplasm, Agostinelli C, Sapienza MR, GIBELLINI, Davide, Gibellini D, Laginestra MA, Mannu C, Maeda T, Croce CM, Tripodo C, Pileri SA, Righi S, Ulbar F, Melle F, Pagano L, Paulli M, Ricci F, Piccaluga PP, Facchetti F, Mancini M, Pimpinelli N   +29 more
core   +2 more sources

P212 | COMPARATIVE ANALYSIS OF MUTATION LANDSCAPE IN MPN PATIENTS WITH SPLANCHNIC VEIN THROMBOSIS AND OTHER VEIN THROMBOSES

Haematologica
Introduction: Myeloproliferative neoplasms (MPNs) are a main cause of splanchnic vein thrombosis (SVT), with JAK2V617F as a known risk factor. The impact of co-occurring mutations on thrombosis risk remains unclear.
L. Fagiolo, V. Boldrini, G. Gaetano Loscocco, G. Coltro, G. Capecchi, G. Borgi, J. Caroprese, C. Matteoli, E. Nacca, G. Rotunno, C. Ghetti, A.M. Vannucchi, P. Guglielmelli   +12 more
doaj  

Moments of a neoplasm

Human Pathology, 2008
During my long career as a practicing pathologist in a university hospital, I have only occasionally met patients sitting at the opposite side of the microscope at my desk. Those of you who have experienced similar situations know that the awkwardness starts when the patient enters the room.
openaire   +3 more sources