Results 91 to 100 of about 266,299 (259)

A case for clarity, consistency, and helpfulness : state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system [PDF]

, 2008
CONTEXT: The Endocrine Society, and a growing number of other organizations, have adopted the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to develop clinical practice guidelines and grade the strength of ...
Vigersky, R. A., Swiglo, B. A., Murad, M. H., Brian A. Swiglo, Holger J. Schünemann, Victor M. Montori, Schünemann, H. J., Montori, V. M., Kunz, R., Regina Kunz, Robert A. Vigersky, Gordon H. Guyatt, Guyatt, G. H., M. H. Murad, Swiglo, Brian A., Montori, Victor M., Guyatt, Gordon H., Schünemann, Holger J., Kunz, Regina, Vigersky, Robert A.   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Standards-based grading : moving toward equality of opportunity and advancement of learning for all students [PDF]

, 2016
This disquisition aims to identify and explore: (1) the unintended, negative consequences of traditional classroom grading practices, (2) an alternative grading practice—standards-based grading—with its positive outcomes, and (3) a process for ...
NC DOCKS at Western Carolina University, Andrews, Catherine, Barnes, Christopher, Gibbs, Jeremy   +3 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Evaluation of concordance between histopathological prognostic findings from prostate needle biopsy samples and serum prostate-specific antigen levels

Medicine Science, 2019
Prostate cancer is the most common cancer in men. Although the prostate-specific antigen (PSA) is still used as a diagnostic and screening test, there are some controversies about its performance for the differentiation of high-risk cancer from low-risk ...
Cengiz Kocak
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a multicenter case-control study.

, 2013
Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the ...
SALVIA, Roberto, Intraductal Papillary Mucinous Neoplasm Study Group, Delle Fave G, Capurso G, BASSI, Claudio, Pezzilli R, Boccia S, Boggi U, Zerbi A, Fabbri C, Ventrucci M, Piciucchi M, Manta R, Carnuccio A, Arcidiacono PG, Tarantino I, FRULLONI, Luca, Leoncini E, Larghi A, Del Chiaro M, Costamagna G, Italian Association for Study of Pancreas   +21 more
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Histopathological features of subcutaneous and cutaneous mast cell tumors in dogs

Acta Veterinaria Scandinavica
Background Mast cell tumors (MCTs) are the most common malignant skin neoplasms in dogs. In the past, the distinction between cutaneous MCTs (cMCTs), originating from the dermis, and subcutaneous MCTs (scMCTs), originating from the subcutaneous tissue ...
Stella Minnoye, Shana De Vos, Samuel Beck, Luc Duchateau, Mike Hubers, Sieglinde David, Ruth Fortrie, Hilde de Rooster   +7 more
doaj   +1 more source