Results 111 to 120 of about 74,828 (311)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prediction of genetic status and grading in glioma based on fusion of macro⁃ and micro⁃imaging features

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To develop a dual⁃layer feature distillation multiple instance learning (DLFD⁃ MIL) model integrating MRI and whole slide image (WSI) features for precise prediction of IDH1 mutation, 1p/19q codeletion, and World Health Organization (WHO ...
LI Zhen, SONG Peng⁃fei, ZHU Rui⁃ze, JIANG Shan, CAO Shi⁃wen, YU Jin⁃hua, SHI Zhi⁃feng   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Role of PD-L1 expression as a biomarker for GEP neuroendocrine neoplasm grading. [PDF]

Cell Death Dis, 2017
Cavalcanti E, Armentano R, Valentini AM, Chieppa M, Caruso ML.   +4 more
europepmc   +1 more source

Expert Consensus Practice Recommendations of the North American Neuroendocrine Tumor Society for the management of high grade gastroenteropancreatic and gynecologic neuroendocrine neoplasms [PDF]

, 2023
Jennifer R. Eads, Þorvarður R. Hálfdánarson, Tim Asmis, Andrew M Belizzi, Emily K. Bergsland, Arvind Dasari, Ghassan El‐Haddad, Michael Frumovitz, Joshua E. Meyer, Erik Mittra, Sten Myrehaug, Eric K. Nakakura, Nitya Raj, Heloisa P. Soares, Brian R. Untch, Namrata Vijayvergia, Jennifer A. Chan   +16 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transformation of Low-Grade Mucinous Neoplasm of the Appendix With Pseudomyxoma Peritonei to High-Grade Sarcomatoid Carcinoma

, 2015
Yu-Nung Chen, Jie-Jen Lee, Shih‐Ping Cheng, Chung‐Hsin Tsai   +3 more
openalex   +2 more sources

Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins [PDF]

, 2016
Morgan L. Cowan, Pedram Argani, Ashley Cimino‐Mathews   +2 more
openalex   +1 more source

World Health Organization grading classification for pancreatic neuroendocrine neoplasms: a comprehensive analysis from a large Chinese institution [PDF]

, 2020
Min Yang, Lin Zeng, Nengwen Ke, Chunlu Tan, Bole Tian, Xu-Bao Liu, Bo Xiang, Yi Zhang   +7 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source