Results 191 to 200 of about 1,245,973 (360)

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

Angiosarcoma primario de mama con metástasis en ovario y axila: un patrón inusual de enfermedad metastásica

open access: yesAvances en Biomedicina, 2016
Primary angiosarcoma of the breast is an uncommon, aggressive neoplasm with an unknown etiology. In this paper, we present a case of a 28 year woman who initially developed primary angiosarcoma of the breast and ovary, followed twenty months later by ...
Jorge Cea García   +3 more
doaj  

Application of machine learning algorithms to predict lymph node metastasis in gastric neuroendocrine neoplasms [PDF]

open access: gold, 2023
Lu Liu   +8 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

CHORIOCARCINOMA (CASE REPORT)

open access: yesСибирский онкологический журнал, 2016
Choriocarcinoma is a malignant neoplasm arising usually from the placenta. It is characterized by early hematogenous metastasis. Due to early metastasis and chemoresistance, patients with choriocarcinoma may have a poor prognosis.
L. I. Kokh
doaj  

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