Results 251 to 260 of about 803,423 (313)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

A Peptide Nucleic Acid‐Functionalized Heterojunction Thin Film Transistor as a Scalable and Reusable Platform for Label‐Free Detection of MicroRNA

Advanced Functional Materials, EarlyView.
A miniaturized, label‐free, and enzyme‐free biosensor (miR‐TFT) enables direct electrical detection of microRNA (miRNA) with single‐nucleotide specificity and a detection limit of 0.6 fM. Built on a tri‐channel In2O3/ZnO heterojunction and functionalized with bespoke peptide nucleic acid (PNA) probes, the device is robust, reusable, and compatible with
Wejdan S. Al Ghamdi, Jorge Romero Domínguez, Erol Hasan, Temur Maksudov, Thomas D. Anthopoulos, Dana Alsulaiman   +5 more
wiley   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, EarlyView.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Urothelial Carcinoma With Bone Metastasis Mimicking Sciatica: A Common Neoplasm With an Uncommon Presentation [PDF]

Ravleen Kaur, LAVLEEN KAUR, Aimen Iqbal, Nirali M. Patel   +3 more
openalex   +1 more source

Cold Atmospheric Plasma Selectively Disrupts Breast Cancer Growth in a Bioprinted 3D Tumor‐Stroma Co‐Culture Model

Advanced Healthcare Materials, EarlyView.
This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret, Jean‐Baptiste Billeau, Michael H. Weber, Derek H. Rosenzweig, Stephan Reuter   +4 more
wiley   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis

Advanced Healthcare Materials, EarlyView.
Radiotherapy damages bone and disrupts osteocyte function, yet mechanically mediated protection remains largely unexplored. This study demonstrates that low‐magnitude, high‐frequency (LMHF) vibration mitigates irradiated osteocyte apoptosis, restores their ability to regulate breast cancer extravasation, and acts synergistically with radiotherapy to ...
Xin Song, Kimberly Seaman, Amel Sassi, Chun‐Yu Lin, Tiankuo Chu, Liyun Wang, Yu Sun, Lidan You   +7 more
wiley   +1 more source