Results 61 to 70 of about 506,616 (289)

iTRAQ-based quantitative proteomic analysis on S100 calcium binding protein A2 in metastasis of laryngeal cancer. [PDF]

PLoS ONE, 2015
Laryngeal cancer is the most frequent neoplasm in the head and neck region, with the vast majority of tumors originating from squamous cells. The survival rate of patients with laryngeal cancer has not improved substantially over the past 25 years.
Cong Zha, Xue Hua Jiang, Shi Fang Peng
doaj   +1 more source

Heat shock proteins in animal neoplasms and human tumours—a comparison [PDF]

Cell Stress and Chaperones, 2008
Heat shock proteins (HSPs) are implicated in all phases of cancer from proliferation, impaired apoptosis and sustained angiogenesis to invasion and metastasis. The presence of abnormal HSP levels in several human tumours suggests that these proteins could be used as diagnostic and/or prognostic markers, whilst the direct correlation between HSP ...
ROMANUCCI, MARIARITA, BASTOW T, DELLA SALDA, Leonardo   +2 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect of STX5 on the metastasis of hepatocellular carcinoma and its mechanism [PDF]

精准医学杂志
Objective To investigate the effect of STX5 on the metastasis of hepatocellular carcinoma (HCC) and its mechanism. Methods Clinical data were collected from 36 patients who were diagnosed with HCC in our hospital from January to December 2015, and the ...
GUO Tingting, ZHAO Ziyin, HE Mingyang, WU Tiansong, XU Bin, ZHANG Bin, WU Zehua, HAN Bing
doaj   +1 more source

Proteomic Analysis of Blood Exosomes from Healthy Females and Breast Cancer Patients Reveals an Association between Different Exosomal Bioactivity on Non-tumorigenic Epithelial Cell and Breast Cancer Cell Migration in Vitro

Biomolecules, 2020
Exosomes are important intercellular communication vehicles, secreted into body fluids by multiple cell types, including tumor cells. They contribute to the metastatic progression of tumor cells through paracrine signalling.
Oleg Tutanov, Evgeniya Orlova, Ksenia Proskura, Alina Grigor’eva, Natalia Yunusova, Yuri Tsentalovich, Antonina Alexandrova, Svetlana Tamkovich   +7 more
doaj   +1 more source

Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia

Electronic Journal of Biotechnology, 2021
Background: Chronic lymphocytic leukaemia (CLL) is a neoplasm of B-cells characterized by variable prognosis. Exploring the proteome of CLL cells may provide insights into the disease.
Suliman A. Alsagaby, Ian A. Brewis, Rajendran Vijayakumar, Fahad A. Alhumaydhi, Ameen S. Alwashmi, Naif K. Alharbi, Waleed Al Abdulmonem, Mariappan Premanathan, Guy Pratt, Christopher Fegan, Christopher Pepper, Paul Brennan   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

The efficacy of HDAC inhibitors in neoplasm treatment

, 2020
Psiuk Dominika, Rocka Agata, Żak Klaudia, Tomczyk Żaklina, Filip Agata. The efficacy of HDAC inhibitors in neoplasm treatment. Journal of Education, Health and Sport. 2020;10(8):244-250. eISSN 2391-8306.
Żak, Klaudia, Filip, Agata, Tomczyk, Żaklina, Psiuk, Dominika, Rocka, Agata   +4 more
core   +1 more source